Swerilactones A and B, Anti-HBV New Lactones from a Tradtional Chinese Herb: Swertia mileensis as a Treatment for Viral Hepatitis
Geng, Chang-An1,2; Jiang, Zhi-Yong1; Ma, Yun-Bao1; Luo, Jie1; Zhang, Xue-Mei1; Wang, Hong-Ling1,2; Shen, Yong1,2; Zuo, Ai-Xue1,2; Zhou, Jun1; Chen, Ji-Jun1
2009-09-17
发表期刊ORGANIC LETTERS
ISSN1523-7060
卷号11期号:18页码:4120-4123
摘要Swerilactones A (1) and B (2), two novel lactones with an unprecedented 6/6/6/6/6 pentacyclic ring system, were isolated from the traditional Chinese herb of Swertia mileensis with activity against the hepatitis virus. Their structures and relative stereochemistry were elucidated based on spectroscopic methods and further confirmed by X-ray single crystal diffraction analysis. In vitro antihepatitis B virus (HBV) assay on Hep G 2.2.15 cell line showed that compound 1 inhibited HBsAg and HBeAg secretion with IC(50) values of 3.66 and 3.58 mM, respectively.
关键词Lamivudine Therapy Virus Alkaloids Constituents
资助信息National Natural Science Foundation of China and Yunnan Province [U0832603]; Xibu Zhiguang Joint-Scholarship
学科领域Chemistry, Organic
DOI10.1021/ol901592f
收录类别SCI ; IC
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000269670700024
引用统计
被引频次:31[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/4264
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
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Geng, Chang-An,Jiang, Zhi-Yong,Ma, Yun-Bao,et al. Swerilactones A and B, Anti-HBV New Lactones from a Tradtional Chinese Herb: Swertia mileensis as a Treatment for Viral Hepatitis[J]. ORGANIC LETTERS,2009,11(18):4120-4123.
APA Geng, Chang-An.,Jiang, Zhi-Yong.,Ma, Yun-Bao.,Luo, Jie.,Zhang, Xue-Mei.,...&Chen, Ji-Jun.(2009).Swerilactones A and B, Anti-HBV New Lactones from a Tradtional Chinese Herb: Swertia mileensis as a Treatment for Viral Hepatitis.ORGANIC LETTERS,11(18),4120-4123.
MLA Geng, Chang-An,et al."Swerilactones A and B, Anti-HBV New Lactones from a Tradtional Chinese Herb: Swertia mileensis as a Treatment for Viral Hepatitis".ORGANIC LETTERS 11.18(2009):4120-4123.
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