Lancifodilactone G: A unique nortriterpenoid isolated from Schisandra lancifolia and its anti-HIV activity
Xiao, WL; Zhu, HJ; Shen, YH; Li, RT; Li, SH; Sun, HD; Zheng, YT; Wang, RR; Lu, Y; Wang, C; Zheng, QT
2005-05-26
发表期刊ORGANIC LETTERS
ISSN1523-7060
卷号7期号:11页码:2145-2148
摘要Lancifodilactone G (1), a novel, highly oxygenated nortriterpenoid featuring a partial enol structure and a spirocyclic moiety, was isolated from the medicinal plant Schisandra lancifolia. Its structure and stereochemistry were determined from extensive one- and two-dimensional NMR and mass spectral data, coupled with single-crystal X-ray analysis. Compound 1 exerted minimal cytotoxicity against C8166 cells (CC50 > 200 mu g/mL) and showed anti-HIV activity with EC50 = 95.47 +/- 14.19 mu g/mL and a selectivity index in the range of 1.82-2.46.
学科领域Chemistry, Organic
DOI10.1021/ol050502n
收录类别SCI ; IC
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000229420400017
引用统计
被引频次:61[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/4260
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Zool, Lab Mol Immunopharmacol, Kunming 650223, Peoples R China
3.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
4.Chinese Acad Sci, Grad Sch, Beijing 10039, Peoples R China
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Xiao, WL,Zhu, HJ,Shen, YH,et al. Lancifodilactone G: A unique nortriterpenoid isolated from Schisandra lancifolia and its anti-HIV activity[J]. ORGANIC LETTERS,2005,7(11):2145-2148.
APA Xiao, WL.,Zhu, HJ.,Shen, YH.,Li, RT.,Li, SH.,...&Zheng, QT.(2005).Lancifodilactone G: A unique nortriterpenoid isolated from Schisandra lancifolia and its anti-HIV activity.ORGANIC LETTERS,7(11),2145-2148.
MLA Xiao, WL,et al."Lancifodilactone G: A unique nortriterpenoid isolated from Schisandra lancifolia and its anti-HIV activity".ORGANIC LETTERS 7.11(2005):2145-2148.
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