Maoecrystal V, cytotoxic diterpenoid with a novel C-19 skeleton from Isodon eriocalyx (Dunn.) Hara

doi:10.1021/ol0481535

	Maoecrystal V, cytotoxic diterpenoid with a novel C-19 skeleton from Isodon eriocalyx (Dunn.) Hara
	Li, SH; Wang, J ; Niu, XM ; Shen, YH ; Zhang, HJ ; Sun, HD; Li, ML ; Tian, QE ; Lu, Y ; Cao, P ; Zheng, QT
	2004-11-11
发表期刊	ORGANIC LETTERS
ISSN	1523-7060
卷号	6 期号:23 页码:4327-4330
摘要	Maoecrystal V (1), a novel C-19 diterpenoid possessing a unique 6,7-seco-6-nor-15(8-->9)-abeo-5,8-epoxy-ent-kaurane skeleton, was isolated from the leaves of a Chinese medicinal herb, Isodon eriocalyx. Its structure was determined by comprehensive NMR and MS spectroscopic analysis and confirmed by single-crystal X-ray diffraction study. Compound 1 showed remarkable inhibitory activity toward HeLa cells with IC50 = 0.02 mug/mL (cis-platin: IC50 = 0.99 mug/mL).
关键词	Ent-kaurane Diterpenoids Var. Laxiflora Rubescens Crystal Dimer
学科领域	Chemistry, Organic
DOI	10.1021/ol0481535
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000224973100049
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/4252
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China 2.Kunming Med Coll, Yunnan Pharmacol Lab Nat Prod, Kunming 650031, Yunnan, Peoples R China 3.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
推荐引用方式 GB/T 7714	Li, SH,Wang, J,Niu, XM,et al. Maoecrystal V, cytotoxic diterpenoid with a novel C-19 skeleton from Isodon eriocalyx (Dunn.) Hara[J]. ORGANIC LETTERS,2004,6(23):4327-4330.
APA	Li, SH.,Wang, J.,Niu, XM.,Shen, YH.,Zhang, HJ.,...&Zheng, QT.(2004).Maoecrystal V, cytotoxic diterpenoid with a novel C-19 skeleton from Isodon eriocalyx (Dunn.) Hara.ORGANIC LETTERS,6(23),4327-4330.
MLA	Li, SH,et al."Maoecrystal V, cytotoxic diterpenoid with a novel C-19 skeleton from Isodon eriocalyx (Dunn.) Hara".ORGANIC LETTERS 6.23(2004):4327-4330.

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