Maoecrystal V, cytotoxic diterpenoid with a novel C-19 skeleton from Isodon eriocalyx (Dunn.) Hara
Li, SH; Wang, J; Niu, XM; Shen, YH; Zhang, HJ; Sun, HD; Li, ML; Tian, QE; Lu, Y; Cao, P; Zheng, QT
2004-11-11
Source PublicationORGANIC LETTERS
ISSN1523-7060
Volume6Issue:23Pages:4327-4330
AbstractMaoecrystal V (1), a novel C-19 diterpenoid possessing a unique 6,7-seco-6-nor-15(8-->9)-abeo-5,8-epoxy-ent-kaurane skeleton, was isolated from the leaves of a Chinese medicinal herb, Isodon eriocalyx. Its structure was determined by comprehensive NMR and MS spectroscopic analysis and confirmed by single-crystal X-ray diffraction study. Compound 1 showed remarkable inhibitory activity toward HeLa cells with IC50 = 0.02 mug/mL (cis-platin: IC50 = 0.99 mug/mL).
KeywordEnt-kaurane Diterpenoids Var. Laxiflora Rubescens Crystal Dimer
Subject AreaChemistry, Organic
DOI10.1021/ol0481535
Indexed BySCI ; IC
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000224973100049
Citation statistics
Cited Times:99[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/4252
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
2.Kunming Med Coll, Yunnan Pharmacol Lab Nat Prod, Kunming 650031, Yunnan, Peoples R China
3.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
Recommended Citation
GB/T 7714
Li, SH,Wang, J,Niu, XM,et al. Maoecrystal V, cytotoxic diterpenoid with a novel C-19 skeleton from Isodon eriocalyx (Dunn.) Hara[J]. ORGANIC LETTERS,2004,6(23):4327-4330.
APA Li, SH.,Wang, J.,Niu, XM.,Shen, YH.,Zhang, HJ.,...&Zheng, QT.(2004).Maoecrystal V, cytotoxic diterpenoid with a novel C-19 skeleton from Isodon eriocalyx (Dunn.) Hara.ORGANIC LETTERS,6(23),4327-4330.
MLA Li, SH,et al."Maoecrystal V, cytotoxic diterpenoid with a novel C-19 skeleton from Isodon eriocalyx (Dunn.) Hara".ORGANIC LETTERS 6.23(2004):4327-4330.
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