A new antitumour ansamitocin from Actinosynnema pretiosum
Wei, Guo-Zhu1; Bai, Lin-Quan2; Yang, Tao1; Ma, Juan1; Zeng, Ying1; Shen, Yue-Mao1; Zhao, Pei-Ji1
2010
发表期刊NATURAL PRODUCT RESEARCH
ISSN1478-6419
卷号24期号:12页码:1146-1150
摘要A new compound of ansamitocin was isolated from the extracts of fermentation medium of mutant strain HGF052 derived from Actinosynnema pretiosum ssp. aurantium ATCC 31565, and identified as N-demethyl-desepoxy-9-methoxy-maytansinol (1) on the basis of extensive spectroscopic methods. Bioassay results showed that compound 1 had cytotoxic activity against HL-60 and BEL-7402 cell lines.
关键词Actinosynnema Pretiosum Ssp Auranticum Atcc 31565 Ansamitocins Spectroscopic Methods Cytotoxic Activity
资助信息National Natural Science Foundation of China [30430020]; Natural Science Foundation of Yunnan Province [2007C096M]
收录类别SCI
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/4246
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Shanghai Jiao Tong Univ, Coll Life Sci & Biotechnol, Lab Microbial Metab, Shanghai 200240, Peoples R China
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Wei, Guo-Zhu,Bai, Lin-Quan,Yang, Tao,et al. A new antitumour ansamitocin from Actinosynnema pretiosum[J]. NATURAL PRODUCT RESEARCH,2010,24(12):1146-1150.
APA Wei, Guo-Zhu.,Bai, Lin-Quan.,Yang, Tao.,Ma, Juan.,Zeng, Ying.,...&Zhao, Pei-Ji.(2010).A new antitumour ansamitocin from Actinosynnema pretiosum.NATURAL PRODUCT RESEARCH,24(12),1146-1150.
MLA Wei, Guo-Zhu,et al."A new antitumour ansamitocin from Actinosynnema pretiosum".NATURAL PRODUCT RESEARCH 24.12(2010):1146-1150.
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