Chemical Constituents from the Leaves and Stems of Schisandra rubriflora
Wei-Lie Xiao; Shi-Ying Yang; Liu-Meng Yang; Guang-Yu Yang; Rui-Rui Wang; Hai-Bo Zhang; Wei Zhao; Jian-Xin Pu; Yang Lu; Yong-Tang Zheng; Han-Dong Sun
2010-02-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号73期号:2页码:221-225
摘要Six new nortriterpenoids, schirubridilactones A-F (1-6). as well as 14 known compounds, were isolated from the leaves and stems of Schisandra rubriflora. The Structures of 1-6 were elucidated oil the basis of spectroscopic methods including HSQC, HMBC, (1)H-(1)H COSY, and ROESY NMR experiments. The relative stereochemistry of I was confirmed through single-crystal X-ray analysis. In addition, compounds 1-6 showed anti-HIV-1 activity with EC(50) values in the range 14.3-80.8 mu g/mL and Selectivity indices in the range 2.2-9.0.
关键词Highly Oxygenated Nortriterpenoids Anti-hiv Activity Dibenzocyclooctadiene Lignans Structure Elucidation Chinensis Schisanartane Triterpenoids Lancifolia Micrantha Acid
资助信息NSFC [20802082, 30830115]; Chinese Academy of Sciences [KSCX1-YW-R-24]; Major State Basic Research Development program of China [2009CB522303, 2009CB940900]; Young Academic and Technical Leader Rising Foundation of Yunnan province [2006PY0147]; Natural Science Foundation of Yunnan Province [2005XY04, 2006B0042Q]
学科领域Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1021/np900849y
收录类别SCI ; IC
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000274803600025
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被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/4226
专题植物化学与西部植物资源持续利用国家重点实验室
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Wei-Lie Xiao,Shi-Ying Yang,Liu-Meng Yang,et al. Chemical Constituents from the Leaves and Stems of Schisandra rubriflora[J]. JOURNAL OF NATURAL PRODUCTS,2010,73(2):221-225.
APA Wei-Lie Xiao.,Shi-Ying Yang.,Liu-Meng Yang.,Guang-Yu Yang.,Rui-Rui Wang.,...&Han-Dong Sun.(2010).Chemical Constituents from the Leaves and Stems of Schisandra rubriflora.JOURNAL OF NATURAL PRODUCTS,73(2),221-225.
MLA Wei-Lie Xiao,et al."Chemical Constituents from the Leaves and Stems of Schisandra rubriflora".JOURNAL OF NATURAL PRODUCTS 73.2(2010):221-225.
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