| Toxicological evaluation of precocene II isolated from Ageratum conyzoides L. (Asteraceae) in Sprague Dawley rats | |
| Adebayo, Abiodun Humphrey1,2; Zeng, Guang Zhi1; Zhang, Yu Mei1; Ji, Chang Jiu1; Akindahunsi, Afolabi Akintunde3; Tan, Ning Hua1 | |
| 2010-05-17 | |
| 发表期刊 | AFRICAN JOURNAL OF BIOTECHNOLOGY
 |
| ISSN | 1684-5315 |
| 卷号 | 9期号:20页码:2938-2944 |
| 摘要 | Precocene II (6,7-dimethoxy-2,2-dimethyl-2-chromene) was the main constituent isolated from Ageratum conyzoides L. and reportedly possessed antifungal activity. The study investigated the isolation, purification and toxicological effects of precocene II from A. conyzoides in Sprague Dawley rats. Precocene II was isolated from the petroleum ether fraction of the plant and the structure was determined by (1)H-, (13)C-,DEPT-NMR and MS spectral techniques. Three groups of eight rats per group were used for the study. While groups B and C were respectively administered with 25 and 50 mg/kg of precocene II in 0.25% CMC-Na for 11 days by gastric intubation, group A was administered with 0.25% CMC-Na and served as the control group. After the last treatment, animals were fasted overnight and on the 12th day, they were injected intravenously with 0.2 ml/kg body weight of phenobarbital. Animals were subsequently dissected from the abdominal region; blood was collected from the pulmonary vein into EDTA anti-coagulated and non anti-coagulated tubes. The liver, kidney and spleen tissues were extracted into separate bottles for histopathological examinations. Results from hematological study indicated that the white blood cell (WBC), red blood cell (RBC), plateletcrit (PCT) and mean corpuscular hemoglobin count (MCHC) were significantly higher across the treated groups. Biochemical result showed that serum glucose level was significantly reduced in the treated groups. No apparent damage was noticed in the liver, kidney and spleen tissues. The result therefore suggests that precocene II possesses hypoglycemic property and could alter some hematopoietic elements but was not toxic to the liver, kidney and spleen tissues. |
| 关键词 | Ageratum Conyzoides Precocene Ii Isolation Toxicological Studies Hematological Markers Hypoglycemic Property |
| 学科领域 | Biotechnology & Applied Microbiology |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000277849800018 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/4186 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Covenant Univ, Coll Sci & Technol, Dept Biol Sci, Ota, Ogun State, Nigeria 3.Fed Univ Technol Akure, Dept Biochem, Akure, Nigeria |
| 推荐引用方式 GB/T 7714 | Adebayo, Abiodun Humphrey,Zeng, Guang Zhi,Zhang, Yu Mei,et al. Toxicological evaluation of precocene II isolated from Ageratum conyzoides L. (Asteraceae) in Sprague Dawley rats[J]. AFRICAN JOURNAL OF BIOTECHNOLOGY,2010,9(20):2938-2944. |
| APA | Adebayo, Abiodun Humphrey,Zeng, Guang Zhi,Zhang, Yu Mei,Ji, Chang Jiu,Akindahunsi, Afolabi Akintunde,&Tan, Ning Hua.(2010).Toxicological evaluation of precocene II isolated from Ageratum conyzoides L. (Asteraceae) in Sprague Dawley rats.AFRICAN JOURNAL OF BIOTECHNOLOGY,9(20),2938-2944. |
| MLA | Adebayo, Abiodun Humphrey,et al."Toxicological evaluation of precocene II isolated from Ageratum conyzoides L. (Asteraceae) in Sprague Dawley rats".AFRICAN JOURNAL OF BIOTECHNOLOGY 9.20(2010):2938-2944. |
| 条目包含的文件 | 下载所有文件 | |||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| 201112280001.pdf（128KB） | 开放获取 | -- | 浏览 下载 | |||
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论