Toxicological evaluation of precocene II isolated from Ageratum conyzoides L. (Asteraceae) in Sprague Dawley rats
Adebayo, Abiodun Humphrey1,2; Zeng, Guang Zhi1; Zhang, Yu Mei1; Ji, Chang Jiu1; Akindahunsi, Afolabi Akintunde3; Tan, Ning Hua1
2010-05-17
发表期刊AFRICAN JOURNAL OF BIOTECHNOLOGY
ISSN1684-5315
卷号9期号:20页码:2938-2944
摘要Precocene II (6,7-dimethoxy-2,2-dimethyl-2-chromene) was the main constituent isolated from Ageratum conyzoides L. and reportedly possessed antifungal activity. The study investigated the isolation, purification and toxicological effects of precocene II from A. conyzoides in Sprague Dawley rats. Precocene II was isolated from the petroleum ether fraction of the plant and the structure was determined by (1)H-, (13)C-,DEPT-NMR and MS spectral techniques. Three groups of eight rats per group were used for the study. While groups B and C were respectively administered with 25 and 50 mg/kg of precocene II in 0.25% CMC-Na for 11 days by gastric intubation, group A was administered with 0.25% CMC-Na and served as the control group. After the last treatment, animals were fasted overnight and on the 12th day, they were injected intravenously with 0.2 ml/kg body weight of phenobarbital. Animals were subsequently dissected from the abdominal region; blood was collected from the pulmonary vein into EDTA anti-coagulated and non anti-coagulated tubes. The liver, kidney and spleen tissues were extracted into separate bottles for histopathological examinations. Results from hematological study indicated that the white blood cell (WBC), red blood cell (RBC), plateletcrit (PCT) and mean corpuscular hemoglobin count (MCHC) were significantly higher across the treated groups. Biochemical result showed that serum glucose level was significantly reduced in the treated groups. No apparent damage was noticed in the liver, kidney and spleen tissues. The result therefore suggests that precocene II possesses hypoglycemic property and could alter some hematopoietic elements but was not toxic to the liver, kidney and spleen tissues.
关键词Ageratum Conyzoides Precocene Ii Isolation Toxicological Studies Hematological Markers Hypoglycemic Property
资助信息Chinese Academy of Sciences (CAS) ; Academy of Sciences for the Developing World (TWAS) ; National Natural Science Foundation of China [30725048]
学科领域Biotechnology & Applied Microbiology
收录类别SCI
语种英语
WOS研究方向Biotechnology & Applied Microbiology
WOS类目Biotechnology & Applied Microbiology
WOS记录号WOS:000277849800018
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/4186
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Covenant Univ, Coll Sci & Technol, Dept Biol Sci, Ota, Ogun State, Nigeria
3.Fed Univ Technol Akure, Dept Biochem, Akure, Nigeria
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Adebayo, Abiodun Humphrey,Zeng, Guang Zhi,Zhang, Yu Mei,et al. Toxicological evaluation of precocene II isolated from Ageratum conyzoides L. (Asteraceae) in Sprague Dawley rats[J]. AFRICAN JOURNAL OF BIOTECHNOLOGY,2010,9(20):2938-2944.
APA Adebayo, Abiodun Humphrey,Zeng, Guang Zhi,Zhang, Yu Mei,Ji, Chang Jiu,Akindahunsi, Afolabi Akintunde,&Tan, Ning Hua.(2010).Toxicological evaluation of precocene II isolated from Ageratum conyzoides L. (Asteraceae) in Sprague Dawley rats.AFRICAN JOURNAL OF BIOTECHNOLOGY,9(20),2938-2944.
MLA Adebayo, Abiodun Humphrey,et al."Toxicological evaluation of precocene II isolated from Ageratum conyzoides L. (Asteraceae) in Sprague Dawley rats".AFRICAN JOURNAL OF BIOTECHNOLOGY 9.20(2010):2938-2944.
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