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题名: Toxicological evaluation of precocene II isolated from Ageratum conyzoides L. (Asteraceae) in Sprague Dawley rats
作者: Adebayo, Abiodun Humphrey1, 2; Zeng, Guang Zhi1; Zhang, Yu Mei1; Ji, Chang Jiu1; Akindahunsi, Afolabi Akintunde3; Tan, Ning Hua1
刊名: AFRICAN JOURNAL OF BIOTECHNOLOGY
关键词: Ageratum conyzoides ; precocene II ; isolation ; toxicological studies ; hematological markers ; hypoglycemic property
英文摘要: Precocene II (6,7-dimethoxy-2,2-dimethyl-2-chromene) was the main constituent isolated from Ageratum conyzoides L. and reportedly possessed antifungal activity. The study investigated the isolation, purification and toxicological effects of precocene II from A. conyzoides in Sprague Dawley rats. Precocene II was isolated from the petroleum ether fraction of the plant and the structure was determined by (1)H-, (13)C-,DEPT-NMR and MS spectral techniques. Three groups of eight rats per group were used for the study. While groups B and C were respectively administered with 25 and 50 mg/kg of precocene II in 0.25% CMC-Na for 11 days by gastric intubation, group A was administered with 0.25% CMC-Na and served as the control group. After the last treatment, animals were fasted overnight and on the 12th day, they were injected intravenously with 0.2 ml/kg body weight of phenobarbital. Animals were subsequently dissected from the abdominal region; blood was collected from the pulmonary vein into EDTA anti-coagulated and non anti-coagulated tubes. The liver, kidney and spleen tissues were extracted into separate bottles for histopathological examinations. Results from hematological study indicated that the white blood cell (WBC), red blood cell (RBC), plateletcrit (PCT) and mean corpuscular hemoglobin count (MCHC) were significantly higher across the treated groups. Biochemical result showed that serum glucose level was significantly reduced in the treated groups. No apparent damage was noticed in the liver, kidney and spleen tissues. The result therefore suggests that precocene II possesses hypoglycemic property and could alter some hematopoietic elements but was not toxic to the liver, kidney and spleen tissues.
出版日期: 2010-05-17
卷号: 9, 期号:20, 页码:2938-2944
语种: 英语
收录类别: SCI
学科分类: Biotechnology & Applied Microbiology
ISSN号: 1684-5315
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/4186
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Covenant Univ, Coll Sci & Technol, Dept Biol Sci, Ota, Ogun State, Nigeria
3.Fed Univ Technol Akure, Dept Biochem, Akure, Nigeria

Recommended Citation:
Adebayo, AH; Zeng, GZ; Zhang, YM; Ji, CJ; Akindahunsi, AA; Tan, NH.Toxicological evaluation of precocene II isolated from Ageratum conyzoides L. (Asteraceae) in Sprague Dawley rats,AFRICAN JOURNAL OF BIOTECHNOLOGY,2010,9(20):2938-2944
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