Xanthohumol, a novel anti-HIV-1 agent purified from Hops Humulus lupulus
Wang, Q; Ding, ZH; Liu, JK; Zheng, YT
AbstractXanthohumol, prenylchacone flavonoid, is a natural product with multi-biofunctions purified from Hops Humulus lupulus. Its anti-HIV-1 activity was tested in the present study. Results showed that xanthohumol inhibited HIV-1 induced cytopathic effects, the production of viral p24 antigen and reverse transcriptase in C8166 lymphocytes at non-cytotoxic concentration. The EC50 values were 0.82, 1.28 and 0.50 mug/ml, respectively. The therapeutic index (TI) was about 10.8. Xanthohumol also inhibited HIV-1 replication in PBMC with EC50 value of 20.74 mug/ml. The activity of recombinant HIV-1 reverse transcriptase and the HIV-1 entry were not inhibited by xanthohumol. The results from this study suggested that xanthohumol is effective against HIV-1 and might serve as an interesting lead compound. It may represent a novel chemotherapeutic agent for HIV-1 infection. However, the mechanism of its anti-HIV-1 effect needs to be further clarified. (C) 2004 Elsevier B.V. All rights reserved.
KeywordXanthohumol Anti-hiv-1 Flavonoid Reverse Transcriptase Hiv Entry
Subject AreaPharmacology & Pharmacy ; Virology
Indexed BySCI
WOS Research AreaPharmacology & Pharmacy ; Virology
WOS SubjectPharmacology & Pharmacy ; Virology
WOS IDWOS:000225626000005
Citation statistics
Cited Times:119[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Affiliation1.Chinese Acad Sci, Kunming Inst Zool, Lab Mol Immunopharmacol, Kunming 650223, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources, Kunming 650204, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Wang, Q,Ding, ZH,Liu, JK,et al. Xanthohumol, a novel anti-HIV-1 agent purified from Hops Humulus lupulus[J]. ANTIVIRAL RESEARCH,2004,64(3):189-194.
APA Wang, Q,Ding, ZH,Liu, JK,&Zheng, YT.(2004).Xanthohumol, a novel anti-HIV-1 agent purified from Hops Humulus lupulus.ANTIVIRAL RESEARCH,64(3),189-194.
MLA Wang, Q,et al."Xanthohumol, a novel anti-HIV-1 agent purified from Hops Humulus lupulus".ANTIVIRAL RESEARCH 64.3(2004):189-194.
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