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题名: Xanthohumol, a novel anti-HIV-1 agent purified from Hops Humulus lupulus
作者: Wang, Q; Ding, ZH; Liu, JK; Zheng, YT
刊名: ANTIVIRAL RESEARCH
关键词: xanthohumol ; anti-HIV-1 ; flavonoid ; reverse transcriptase ; HIV entry
英文摘要: Xanthohumol, prenylchacone flavonoid, is a natural product with multi-biofunctions purified from Hops Humulus lupulus. Its anti-HIV-1 activity was tested in the present study. Results showed that xanthohumol inhibited HIV-1 induced cytopathic effects, the production of viral p24 antigen and reverse transcriptase in C8166 lymphocytes at non-cytotoxic concentration. The EC50 values were 0.82, 1.28 and 0.50 mug/ml, respectively. The therapeutic index (TI) was about 10.8. Xanthohumol also inhibited HIV-1 replication in PBMC with EC50 value of 20.74 mug/ml. The activity of recombinant HIV-1 reverse transcriptase and the HIV-1 entry were not inhibited by xanthohumol. The results from this study suggested that xanthohumol is effective against HIV-1 and might serve as an interesting lead compound. It may represent a novel chemotherapeutic agent for HIV-1 infection. However, the mechanism of its anti-HIV-1 effect needs to be further clarified. (C) 2004 Elsevier B.V. All rights reserved.
出版日期: 2004-12-01
卷号: 64, 期号:3, 页码:189-194
DOI标识: 10.1016/j.antiviral.2004.08.005
语种: 英语
ISSN号: 0166-3542
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/4178
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Zool, Lab Mol Immunopharmacol, Kunming 650223, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources, Kunming 650204, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

Recommended Citation:
Wang, Q; Ding, ZH; Liu, JK; Zheng, YT.Xanthohumol, a novel anti-HIV-1 agent purified from Hops Humulus lupulus,ANTIVIRAL RESEARCH,2004,64(3):189-194
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