Xanthohumol, a novel anti-HIV-1 agent purified from Hops Humulus lupulus
Wang, Q; Ding, ZH; Liu, JK; Zheng, YT
2004-12-01
发表期刊ANTIVIRAL RESEARCH
ISSN0166-3542
卷号64期号:3页码:189-194
摘要Xanthohumol, prenylchacone flavonoid, is a natural product with multi-biofunctions purified from Hops Humulus lupulus. Its anti-HIV-1 activity was tested in the present study. Results showed that xanthohumol inhibited HIV-1 induced cytopathic effects, the production of viral p24 antigen and reverse transcriptase in C8166 lymphocytes at non-cytotoxic concentration. The EC50 values were 0.82, 1.28 and 0.50 mug/ml, respectively. The therapeutic index (TI) was about 10.8. Xanthohumol also inhibited HIV-1 replication in PBMC with EC50 value of 20.74 mug/ml. The activity of recombinant HIV-1 reverse transcriptase and the HIV-1 entry were not inhibited by xanthohumol. The results from this study suggested that xanthohumol is effective against HIV-1 and might serve as an interesting lead compound. It may represent a novel chemotherapeutic agent for HIV-1 infection. However, the mechanism of its anti-HIV-1 effect needs to be further clarified. (C) 2004 Elsevier B.V. All rights reserved.
关键词Xanthohumol Anti-hiv-1 Flavonoid Reverse Transcriptase Hiv Entry
学科领域Pharmacology & Pharmacy ; Virology
DOI10.1016/j.antiviral.2004.08.005
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy ; Virology
WOS类目Pharmacology & Pharmacy ; Virology
WOS记录号WOS:000225626000005
引用统计
被引频次:118[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/4178
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Zool, Lab Mol Immunopharmacol, Kunming 650223, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources, Kunming 650204, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
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Wang, Q,Ding, ZH,Liu, JK,et al. Xanthohumol, a novel anti-HIV-1 agent purified from Hops Humulus lupulus[J]. ANTIVIRAL RESEARCH,2004,64(3):189-194.
APA Wang, Q,Ding, ZH,Liu, JK,&Zheng, YT.(2004).Xanthohumol, a novel anti-HIV-1 agent purified from Hops Humulus lupulus.ANTIVIRAL RESEARCH,64(3),189-194.
MLA Wang, Q,et al."Xanthohumol, a novel anti-HIV-1 agent purified from Hops Humulus lupulus".ANTIVIRAL RESEARCH 64.3(2004):189-194.
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