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题名: Rubiyunnanins C-H, cytotoxic cyclic hexapeptides from Rubia yunnanensis inhibiting nitric oxide production and NF-kappa B activation
作者: Fan, Jun-Ting1, 2; Su, Jia1, 2; Peng, Yan-Min2, 3; null(李艳)1; Li, Jia3; Zhou, Yu-Bo3; Zeng, Guang-Zhi1; Yan, He1, 2; Tan, Ning-Hua1
刊名: BIOORGANIC & MEDICINAL CHEMISTRY
关键词: Rubia yunnanensis ; Rubiyunnanins C-H ; Cyclopeptides ; Cytotoxicity ; Inhibition of NO production ; NF-kappa B pathway inhibitors
英文摘要: Six new (rubiyunnanins C-H, 1-6) and five known (7-11) cyclic hexapeptides were isolated from the roots of Rubia yunnanensis (Franch.) Diels. The structures and stereochemistry of 1-6 were established by extensive spectroscopic analyses and chemical methods. All compounds (1-11) not only exhibited cytotoxic activities against a panel of eleven cancer cell lines with IC(50) values ranging from 0.001 to 56.24 mu M, but also exerted inhibitory activities against nitric oxide (NO) production in LPS and IFN-gamma-induced RAW 264.7 murine macrophages with IC(50) values ranging from 0.05 to 12.68 mu M. Furthermore, this is the first time it is being reported that compounds 2 and 7-10 significantly inhibited TNF-alpha-induced NF-kappa B activation in HEK-293-NF-kappa B luciferase stable cells with IC(50) values of 35.07, 0.03, 1.69, 12.64 and 1.18 mu M, respectively. (C) 2010 Elsevier Ltd. All rights reserved.
出版日期: 2010-12-01
卷号: 18, 期号:23, 页码:8226-8234
语种: 英语
收录类别: SCI
学科分类: Biochemistry & Molecular Biology; Chemistry, Medicinal; Chemistry, Organic
ISSN号: 0968-0896
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/4158
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screen, Shanghai 201203, Peoples R China

Recommended Citation:
Fan, JT; Su, J; Peng, YM; Li, Y; Li, J; Zhou, YB; Zeng, GZ; Yan, H; Tan, NH.Rubiyunnanins C-H, cytotoxic cyclic hexapeptides from Rubia yunnanensis inhibiting nitric oxide production and NF-kappa B activation,BIOORGANIC & MEDICINAL CHEMISTRY,2010,18(23):8226-8234
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