Rubiyunnanins C-H, cytotoxic cyclic hexapeptides from Rubia yunnanensis inhibiting nitric oxide production and NF-kappa B activation
Fan, Jun-Ting1,2; Su, Jia1,2; Peng, Yan-Min2,3; Li, Yan1; Li, Jia3; Zhou, Yu-Bo3; Zeng, Guang-Zhi1; Yan, He1,2; Tan, Ning-Hua1
2010-12-01
发表期刊BIOORGANIC & MEDICINAL CHEMISTRY
ISSN0968-0896
卷号18期号:23页码:8226-8234
摘要Six new (rubiyunnanins C-H, 1-6) and five known (7-11) cyclic hexapeptides were isolated from the roots of Rubia yunnanensis (Franch.) Diels. The structures and stereochemistry of 1-6 were established by extensive spectroscopic analyses and chemical methods. All compounds (1-11) not only exhibited cytotoxic activities against a panel of eleven cancer cell lines with IC(50) values ranging from 0.001 to 56.24 mu M, but also exerted inhibitory activities against nitric oxide (NO) production in LPS and IFN-gamma-induced RAW 264.7 murine macrophages with IC(50) values ranging from 0.05 to 12.68 mu M. Furthermore, this is the first time it is being reported that compounds 2 and 7-10 significantly inhibited TNF-alpha-induced NF-kappa B activation in HEK-293-NF-kappa B luciferase stable cells with IC(50) values of 35.07, 0.03, 1.69, 12.64 and 1.18 mu M, respectively. (C) 2010 Elsevier Ltd. All rights reserved.
关键词Rubia Yunnanensis Rubiyunnanins C-h Cyclopeptides Cytotoxicity Inhibition Of No Production Nf-kappa b Pathway Inhibitors
资助信息National Natural Science Foundation of China [30725048]; National Basic Research Program of China [2009 CB522300]; Chinese Academy of Sciences [KSCX2-YW-R-177]; Science and Technology Department of Yunnan Province [2008OC011]; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences
收录类别SCI
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/4158
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screen, Shanghai 201203, Peoples R China
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Fan, Jun-Ting,Su, Jia,Peng, Yan-Min,et al. Rubiyunnanins C-H, cytotoxic cyclic hexapeptides from Rubia yunnanensis inhibiting nitric oxide production and NF-kappa B activation[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2010,18(23):8226-8234.
APA Fan, Jun-Ting.,Su, Jia.,Peng, Yan-Min.,Li, Yan.,Li, Jia.,...&Tan, Ning-Hua.(2010).Rubiyunnanins C-H, cytotoxic cyclic hexapeptides from Rubia yunnanensis inhibiting nitric oxide production and NF-kappa B activation.BIOORGANIC & MEDICINAL CHEMISTRY,18(23),8226-8234.
MLA Fan, Jun-Ting,et al."Rubiyunnanins C-H, cytotoxic cyclic hexapeptides from Rubia yunnanensis inhibiting nitric oxide production and NF-kappa B activation".BIOORGANIC & MEDICINAL CHEMISTRY 18.23(2010):8226-8234.
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