Design, synthesis, and SAR analysis of cytotoxic sinapyl alcohol derivatives

doi:10.1016/j.bmc.2005.10.056

	Design, synthesis, and SAR analysis of cytotoxic sinapyl alcohol derivatives
	Zou, HB ; Dong, SY ; Zhou, CX ; Hu, LH ; Wu, YH ; Li, HB ; Gong, JX ; Sun, LL ; Wu, XM ; Bai, H ; Fan, BT ; Hao, XJ; Stockigt, J ; Zhao, Y
	2006-03-15
发表期刊	BIOORGANIC & MEDICINAL CHEMISTRY
ISSN	0968-0896
卷号	14 期号:6 页码:2060-2071
摘要	Five series totalling 51 of sinapyl alcohol derivatives were designed and synthesized. Their cytotoxicity analyses were performed oil six human tumor cell lines Such as PC-3. CNE, KB, A549, BEL-7404, and HeLa. Certain sinapyl alcohol derivatives showed significant cytotoxic activities. Compound 14d exhibited especially potent cytotoxicity against the BEL-7404 cell line with an IC50 value of 0.7 mu M, which showed more cytotoxic activity than the positive control, cisplatin. The structure-cytotoxicity relationships were discussed and the CoMFA analysis was performed using the cytotoxic data against HeLa cells as a template. (c) 2005 Elsevier Ltd. All rights reserved.
关键词	Sinapyl Alcohol Derivatives Synthesis Cytotoxicity Comfa Analysis
学科领域	Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Chemistry, Organic
DOI	10.1016/j.bmc.2005.10.056
收录类别	SCI
语种	英语
WOS记录号	WOS:000235579900041
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/4150
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Zhejiang Univ, Coll Pharmaceut Sci, Dept Tradit Chinese Med & Nat Drug Res, Hangzhou 310031, Peoples R China 2.Zhejiang Hisun Nat Pharmaceut R&D Co Ltd, Hangzhou 310006, Peoples R China 3.Univ Paris 07, CNRS, UMR 7086, ITODYS, F-75005 Paris, France 4.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China 5.Johannes Gutenberg Univ Mainz, Inst Pharm, Lehrstuhl Pharmazeut Biol, D-55099 Mainz, Germany
推荐引用方式 GB/T 7714	Zou, HB,Dong, SY,Zhou, CX,et al. Design, synthesis, and SAR analysis of cytotoxic sinapyl alcohol derivatives[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2006,14(6):2060-2071.
APA	Zou, HB.,Dong, SY.,Zhou, CX.,Hu, LH.,Wu, YH.,...&Zhao, Y.(2006).Design, synthesis, and SAR analysis of cytotoxic sinapyl alcohol derivatives.BIOORGANIC & MEDICINAL CHEMISTRY,14(6),2060-2071.
MLA	Zou, HB,et al."Design, synthesis, and SAR analysis of cytotoxic sinapyl alcohol derivatives".BIOORGANIC & MEDICINAL CHEMISTRY 14.6(2006):2060-2071.

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