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题名: Design, synthesis, and SAR analysis of cytotoxic sinapyl alcohol derivatives
作者: Zou, HB; Dong, SY; Zhou, CX; Hu, LH; Wu, YH; Li, HB; Gong, JX; Sun, LL; Wu, XM; Bai, H; Fan, BT; null(郝小江); Stockigt, J; Zhao, Y
刊名: BIOORGANIC & MEDICINAL CHEMISTRY
关键词: sinapyl alcohol derivatives ; synthesis ; cytotoxicity ; CoMFA analysis
英文摘要: Five series totalling 51 of sinapyl alcohol derivatives were designed and synthesized. Their cytotoxicity analyses were performed oil six human tumor cell lines Such as PC-3. CNE, KB, A549, BEL-7404, and HeLa. Certain sinapyl alcohol derivatives showed significant cytotoxic activities. Compound 14d exhibited especially potent cytotoxicity against the BEL-7404 cell line with an IC50 value of 0.7 mu M, which showed more cytotoxic activity than the positive control, cisplatin. The structure-cytotoxicity relationships were discussed and the CoMFA analysis was performed using the cytotoxic data against HeLa cells as a template. (c) 2005 Elsevier Ltd. All rights reserved.
出版日期: 2006-03-15
卷号: 14, 期号:6, 页码:2060-2071
语种: 英语
收录类别: SCI
学科分类: Biochemistry & Molecular Biology; Chemistry, Medicinal; Chemistry, Organic
ISSN号: 0968-0896
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/4150
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Zhejiang Univ, Coll Pharmaceut Sci, Dept Tradit Chinese Med & Nat Drug Res, Hangzhou 310031, Peoples R China
2.Zhejiang Hisun Nat Pharmaceut R&D Co Ltd, Hangzhou 310006, Peoples R China
3.Univ Paris 07, CNRS, UMR 7086, ITODYS, F-75005 Paris, France
4.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
5.Johannes Gutenberg Univ Mainz, Inst Pharm, Lehrstuhl Pharmazeut Biol, D-55099 Mainz, Germany

Recommended Citation:
Hong, BZ; Sheng, YD; Chang, XZ; Li, HH; Yi, HW; Hai, BL; Jing, XG; Sun, LL; Xiu, MW; Hua, B; Bo, TF; Xiao, JH; Stockigt, J; Yu, Z.Design, synthesis, and SAR analysis of cytotoxic sinapyl alcohol derivatives,BIOORGANIC & MEDICINAL CHEMISTRY,2006,14(6):2060-2071
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