Design, synthesis, and SAR analysis of cytotoxic sinapyl alcohol derivatives
Zou, HB; Dong, SY; Zhou, CX; Hu, LH; Wu, YH; Li, HB; Gong, JX; Sun, LL; Wu, XM; Bai, H; Fan, BT; Hao, XJ; Stockigt, J; Zhao, Y
2006-03-15
发表期刊BIOORGANIC & MEDICINAL CHEMISTRY
ISSN0968-0896
卷号14期号:6页码:2060-2071
摘要Five series totalling 51 of sinapyl alcohol derivatives were designed and synthesized. Their cytotoxicity analyses were performed oil six human tumor cell lines Such as PC-3. CNE, KB, A549, BEL-7404, and HeLa. Certain sinapyl alcohol derivatives showed significant cytotoxic activities. Compound 14d exhibited especially potent cytotoxicity against the BEL-7404 cell line with an IC50 value of 0.7 mu M, which showed more cytotoxic activity than the positive control, cisplatin. The structure-cytotoxicity relationships were discussed and the CoMFA analysis was performed using the cytotoxic data against HeLa cells as a template. (c) 2005 Elsevier Ltd. All rights reserved.
关键词Sinapyl Alcohol Derivatives Synthesis Cytotoxicity Comfa Analysis
学科领域Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Chemistry, Organic
DOI10.1016/j.bmc.2005.10.056
收录类别SCI
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry
WOS类目Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Chemistry, Organic
WOS记录号WOS:000235579900041
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/4150
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Zhejiang Univ, Coll Pharmaceut Sci, Dept Tradit Chinese Med & Nat Drug Res, Hangzhou 310031, Peoples R China
2.Zhejiang Hisun Nat Pharmaceut R&D Co Ltd, Hangzhou 310006, Peoples R China
3.Univ Paris 07, CNRS, UMR 7086, ITODYS, F-75005 Paris, France
4.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
5.Johannes Gutenberg Univ Mainz, Inst Pharm, Lehrstuhl Pharmazeut Biol, D-55099 Mainz, Germany
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GB/T 7714
Zou, HB,Dong, SY,Zhou, CX,et al. Design, synthesis, and SAR analysis of cytotoxic sinapyl alcohol derivatives[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2006,14(6):2060-2071.
APA Zou, HB.,Dong, SY.,Zhou, CX.,Hu, LH.,Wu, YH.,...&Zhao, Y.(2006).Design, synthesis, and SAR analysis of cytotoxic sinapyl alcohol derivatives.BIOORGANIC & MEDICINAL CHEMISTRY,14(6),2060-2071.
MLA Zou, HB,et al."Design, synthesis, and SAR analysis of cytotoxic sinapyl alcohol derivatives".BIOORGANIC & MEDICINAL CHEMISTRY 14.6(2006):2060-2071.
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