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题名: Cytotoxic isoprenylated xanthones from Cudrania tricuspidata
作者: Zou, YS; Hou, AJ; Zhu, GF; Chen, YF; null(孙汉董); null(赵勤实)
刊名: BIOORGANIC & MEDICINAL CHEMISTRY
关键词: ROOT BARK ; PRENYLATED XANTHONES ; MORACEAE PLANTS ; MACLURA-POMIFERA ; COMPONENTS ; CONSTITUENTS ; COCHINCHINENSIS ; FLAVONES ; WOOD
英文摘要: Eight new isoprenylated xanthones, cudratricusxanthones A-H (1-8), were isolated from the roots of Cudrania tricuspidata, together with ten known compounds, cudraxanthones H (9) and M (10), xanthone V,a (11), toxyloxanthone C (12), macluraxanthone B (13), 1-hydroxy-3, 6, 7-trimethoxyxanthone (14), cycloartocarpesin (15), artocarpesin (16), cudraflavone B (17), and kaempferol (18). Their structures were characterized by spectroscopic methods. Xanthones 5, 7, 10, and 12 showed inhibitory effects on four kinds of human digestive apparatus tumor cell lines (HCT-116, SMMC-7721, SGC-7901, and BGC-823) with IC50 values of 1.6-11.8 mug/mL. Xanthones 2, 4, and 11 displayed significant cytotoxicity against HCT-116, SMMC-7721, and SGC-7901 (IC50 = 1.3-9.8 mug/mL). Flavonoids 15-17 were almost inactive. (C) 2004 Elsevier Ltd. All rights reserved.
出版日期: 2004-04-15
卷号: 12, 期号:8, 页码:1947-1953
语种: 英语
收录类别: SCI
学科分类: Biochemistry & Molecular Biology; Chemistry, Medicinal; Chemistry, Organic
ISSN号: 0968-0896
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/4148
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Fudan Univ, Sch Pharm, Dept Pharmacognosy, Shanghai 200032, Peoples R China
2.Shanghai Univ Tradit Chinese Med, Sch Chinese Pharm, Shanghai 201203, Peoples R China
3.Acad Sinica, Kunming Inst Bot, Lab Phytochem, Kunming 650204, Yunnan, Peoples R China

Recommended Citation:
Zou, YS; Hou, AJ; Zhu, GF; Chen, YF; Sun, HD; Zhao, QS.Cytotoxic isoprenylated xanthones from Cudrania tricuspidata,BIOORGANIC & MEDICINAL CHEMISTRY,2004,12(8):1947-1953
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