Cytotoxic isoprenylated xanthones from Cudrania tricuspidata
Zou, YS; Hou, AJ; Zhu, GF; Chen, YF; Sun, HD; Zhao, QS
2004-04-15
发表期刊BIOORGANIC & MEDICINAL CHEMISTRY
ISSN0968-0896
卷号12期号:8页码:1947-1953
摘要Eight new isoprenylated xanthones, cudratricusxanthones A-H (1-8), were isolated from the roots of Cudrania tricuspidata, together with ten known compounds, cudraxanthones H (9) and M (10), xanthone V,a (11), toxyloxanthone C (12), macluraxanthone B (13), 1-hydroxy-3, 6, 7-trimethoxyxanthone (14), cycloartocarpesin (15), artocarpesin (16), cudraflavone B (17), and kaempferol (18). Their structures were characterized by spectroscopic methods. Xanthones 5, 7, 10, and 12 showed inhibitory effects on four kinds of human digestive apparatus tumor cell lines (HCT-116, SMMC-7721, SGC-7901, and BGC-823) with IC50 values of 1.6-11.8 mug/mL. Xanthones 2, 4, and 11 displayed significant cytotoxicity against HCT-116, SMMC-7721, and SGC-7901 (IC50 = 1.3-9.8 mug/mL). Flavonoids 15-17 were almost inactive. (C) 2004 Elsevier Ltd. All rights reserved.
关键词Root Bark Prenylated Xanthones Moraceae Plants Maclura-pomifera Components Constituents Cochinchinensis Flavones Wood
学科领域Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Chemistry, Organic
DOI10.1016/j.bmc.2004.01.030
收录类别SCI
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry
WOS类目Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Chemistry, Organic
WOS记录号WOS:000220754600012
引用统计
被引频次:77[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/4148
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Fudan Univ, Sch Pharm, Dept Pharmacognosy, Shanghai 200032, Peoples R China
2.Shanghai Univ Tradit Chinese Med, Sch Chinese Pharm, Shanghai 201203, Peoples R China
3.Acad Sinica, Kunming Inst Bot, Lab Phytochem, Kunming 650204, Yunnan, Peoples R China
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GB/T 7714
Zou, YS,Hou, AJ,Zhu, GF,et al. Cytotoxic isoprenylated xanthones from Cudrania tricuspidata[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2004,12(8):1947-1953.
APA Zou, YS,Hou, AJ,Zhu, GF,Chen, YF,Sun, HD,&Zhao, QS.(2004).Cytotoxic isoprenylated xanthones from Cudrania tricuspidata.BIOORGANIC & MEDICINAL CHEMISTRY,12(8),1947-1953.
MLA Zou, YS,et al."Cytotoxic isoprenylated xanthones from Cudrania tricuspidata".BIOORGANIC & MEDICINAL CHEMISTRY 12.8(2004):1947-1953.
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