| Recombination of diterpenoid structure units: Synthesis of antitumor amides bearing functionalized bicyclo[3.2.1]octane ring | |
Mao, Zewei1; Li, Yan2 ; Chen, Jingbo1; Wang, Yuanyuan2; Zhang, Hongbin1
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| 2010-07-15 | |
| 发表期刊 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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| ISSN | 0960-894X |
| 卷号 | 20期号:14页码:4116-4119 |
| 摘要 | In this work, 23 new amides (14-36) bearing a representative diterpenoid structure unit, the functionalized bicyclo[3.2.1]octane ring, have been synthesized and its antitumor potential is studied. In vitro studies demonstrate that a number of amides with the bicyclo[3.2.1]oct-3-en-2-one subunit are active against HL-60, SMMC-7721, A-549, SK-BR-3, and PANC-1 tumor cell lines. The hybrid derivative, compound 20, was found to be the most potent compound (IC(50) = 1.05 mu M against HL-60) and more active than cisplatin (DDP), the positive control. Additionally, compound 20 exhibited broad spectrum in vitro anticancer activity with IC(50) values of 1.1-4.3 mu M against the five tested cancer cell lines. (C) 2010 Elsevier Ltd. All rights reserved. |
| 关键词 | Amide Diterpenoid Structure Unit Bicyclo[3.2.1]Octane Ring System Antitumor Activity |
| 学科领域 | Chemistry, Medicinal ; Chemistry, Organic |
| DOI | 10.1016/j.bmcl.2010.05.075 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000279258800028 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/4146 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Mao, Zewei,Li, Yan,Chen, Jingbo,et al. Recombination of diterpenoid structure units: Synthesis of antitumor amides bearing functionalized bicyclo[3.2.1]octane ring[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2010,20(14):4116-4119. |
| APA | Mao, Zewei,Li, Yan,Chen, Jingbo,Wang, Yuanyuan,&Zhang, Hongbin.(2010).Recombination of diterpenoid structure units: Synthesis of antitumor amides bearing functionalized bicyclo[3.2.1]octane ring.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,20(14),4116-4119. |
| MLA | Mao, Zewei,et al."Recombination of diterpenoid structure units: Synthesis of antitumor amides bearing functionalized bicyclo[3.2.1]octane ring".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 20.14(2010):4116-4119. |
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| 201112280022.pdf（424KB） | 开放获取 | -- | 浏览 请求全文 | |||
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