Recombination of diterpenoid structure units: Synthesis of antitumor amides bearing functionalized bicyclo[3.2.1]octane ring
Mao, Zewei1; Li, Yan2; Chen, Jingbo1; Wang, Yuanyuan2; Zhang, Hongbin1
2010-07-15
发表期刊BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN0960-894X
卷号20期号:14页码:4116-4119
摘要In this work, 23 new amides (14-36) bearing a representative diterpenoid structure unit, the functionalized bicyclo[3.2.1]octane ring, have been synthesized and its antitumor potential is studied. In vitro studies demonstrate that a number of amides with the bicyclo[3.2.1]oct-3-en-2-one subunit are active against HL-60, SMMC-7721, A-549, SK-BR-3, and PANC-1 tumor cell lines. The hybrid derivative, compound 20, was found to be the most potent compound (IC(50) = 1.05 mu M against HL-60) and more active than cisplatin (DDP), the positive control. Additionally, compound 20 exhibited broad spectrum in vitro anticancer activity with IC(50) values of 1.1-4.3 mu M against the five tested cancer cell lines. (C) 2010 Elsevier Ltd. All rights reserved.
关键词Amide Diterpenoid Structure Unit Bicyclo[3.2.1]Octane Ring System Antitumor Activity
资助信息Natural Science Foundation of China [20832005, 20925205]; National Basic Research Program of China [2009CB522300]; Natural Science Foundation of Yunnan Province [2007B0006Z]
学科领域Chemistry, Medicinal ; Chemistry, Organic
DOI10.1016/j.bmcl.2010.05.075
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy ; Chemistry
WOS类目Chemistry, Medicinal ; Chemistry, Organic
WOS记录号WOS:000279258800028
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/4146
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
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GB/T 7714
Mao, Zewei,Li, Yan,Chen, Jingbo,et al. Recombination of diterpenoid structure units: Synthesis of antitumor amides bearing functionalized bicyclo[3.2.1]octane ring[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2010,20(14):4116-4119.
APA Mao, Zewei,Li, Yan,Chen, Jingbo,Wang, Yuanyuan,&Zhang, Hongbin.(2010).Recombination of diterpenoid structure units: Synthesis of antitumor amides bearing functionalized bicyclo[3.2.1]octane ring.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,20(14),4116-4119.
MLA Mao, Zewei,et al."Recombination of diterpenoid structure units: Synthesis of antitumor amides bearing functionalized bicyclo[3.2.1]octane ring".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 20.14(2010):4116-4119.
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