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题名: Recombination of diterpenoid structure units: Synthesis of antitumor amides bearing functionalized bicyclo[3.2.1]octane ring
作者: Mao, Zewei1; null(李艳)2; Chen, Jingbo1; Wang, Yuanyuan2; Zhang, Hongbin1
刊名: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
关键词: Amide ; Diterpenoid structure unit ; Bicyclo[3.2.1]octane ring system ; Antitumor activity
英文摘要: In this work, 23 new amides (14-36) bearing a representative diterpenoid structure unit, the functionalized bicyclo[3.2.1]octane ring, have been synthesized and its antitumor potential is studied. In vitro studies demonstrate that a number of amides with the bicyclo[3.2.1]oct-3-en-2-one subunit are active against HL-60, SMMC-7721, A-549, SK-BR-3, and PANC-1 tumor cell lines. The hybrid derivative, compound 20, was found to be the most potent compound (IC(50) = 1.05 mu M against HL-60) and more active than cisplatin (DDP), the positive control. Additionally, compound 20 exhibited broad spectrum in vitro anticancer activity with IC(50) values of 1.1-4.3 mu M against the five tested cancer cell lines. (C) 2010 Elsevier Ltd. All rights reserved.
出版日期: 2010-07-15
卷号: 20, 期号:14, 页码:4116-4119
DOI标识: 10.1016/j.bmcl.2010.05.075
语种: 英语
收录类别: SCI
学科分类: Chemistry, Medicinal; Chemistry, Organic
ISSN号: 0960-894X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/4146
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China

Recommended Citation:
Mao, ZW; Li, Y; Chen, JB; Wang, YY; Zhang, HB.Recombination of diterpenoid structure units: Synthesis of antitumor amides bearing functionalized bicyclo[3.2.1]octane ring,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2010,20(14):4116-4119
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