| Fatty acid synthase inhibitors of phenolic constituents isolated from Garcinia mangostana | |
Jiang, He Zhong2; Quan, Xiao Fang1; Tian, Wei Xi1; Hu, Jiang Miao2; Wang, Peng Cheng2; Huang, Sheng Zhuo2; Cheng, Zhong Quan2; Liang, Wen Juan2; Zhou, Jun2 ; Ma, Xiao Feng1; Zhao, You Xing2,3
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| 2010-10-15 | |
| 发表期刊 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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| ISSN | 0960-894X |
| 卷号 | 20期号:20页码:6045-6047 |
| 摘要 | Natural inhibitors of fatty acid synthase (FAS) are emerging as potential therapeutic agents to treat cancer and obesity. The bioassay-guided chemical investigation of the hulls of Garcinia mangostana led to the isolation of 13 phenolic compounds (1-13) mainly including xanthone and benzophenone, in which compounds 7, 8, 9, 10, and 11 were isolated from this plant for the first time and compound 9 was a new natural product. These isolates possess strong inhibitory activity of FAS with the IC(50) values ranging from 1.24 to 91.07 mu M. The study indicates that two types of natural products, xanthones and benzophenones, could be considered as promising FAS inhibitors. (c) 2010 Elsevier Ltd. All rights reserved. |
| 关键词 | Fatty Acid Synthase (Fas) Garcinia Mangostana Xanthone Benzophenone Fas Inhibitors |
| 学科领域 | Chemistry, Medicinal ; Chemistry, Organic |
| DOI | 10.1016/j.bmcl.2010.08.061 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000281963700019 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/4144 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Grad Univ, Coll Life Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 3.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Haikou 571101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, He Zhong,Quan, Xiao Fang,Tian, Wei Xi,et al. Fatty acid synthase inhibitors of phenolic constituents isolated from Garcinia mangostana[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2010,20(20):6045-6047. |
| APA | Jiang, He Zhong.,Quan, Xiao Fang.,Tian, Wei Xi.,Hu, Jiang Miao.,Wang, Peng Cheng.,...&Zhao, You Xing.(2010).Fatty acid synthase inhibitors of phenolic constituents isolated from Garcinia mangostana.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,20(20),6045-6047. |
| MLA | Jiang, He Zhong,et al."Fatty acid synthase inhibitors of phenolic constituents isolated from Garcinia mangostana".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 20.20(2010):6045-6047. |
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