Fatty acid synthase inhibitors of phenolic constituents isolated from Garcinia mangostana
Jiang, He Zhong2; Quan, Xiao Fang1; Tian, Wei Xi1; Hu, Jiang Miao2; Wang, Peng Cheng2; Huang, Sheng Zhuo2; Cheng, Zhong Quan2; Liang, Wen Juan2; Zhou, Jun2; Ma, Xiao Feng1; Zhao, You Xing2,3
2010-10-15
Source PublicationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN0960-894X
Volume20Issue:20Pages:6045-6047
AbstractNatural inhibitors of fatty acid synthase (FAS) are emerging as potential therapeutic agents to treat cancer and obesity. The bioassay-guided chemical investigation of the hulls of Garcinia mangostana led to the isolation of 13 phenolic compounds (1-13) mainly including xanthone and benzophenone, in which compounds 7, 8, 9, 10, and 11 were isolated from this plant for the first time and compound 9 was a new natural product. These isolates possess strong inhibitory activity of FAS with the IC(50) values ranging from 1.24 to 91.07 mu M. The study indicates that two types of natural products, xanthones and benzophenones, could be considered as promising FAS inhibitors. (c) 2010 Elsevier Ltd. All rights reserved.
KeywordFatty Acid Synthase (Fas) Garcinia Mangostana Xanthone Benzophenone Fas Inhibitors
Subject AreaChemistry, Medicinal ; Chemistry, Organic
DOI10.1016/j.bmcl.2010.08.061
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy ; Chemistry
WOS SubjectChemistry, Medicinal ; Chemistry, Organic
WOS IDWOS:000281963700019
Citation statistics
Cited Times:38[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/4144
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Grad Univ, Coll Life Sci, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
3.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Haikou 571101, Peoples R China
Recommended Citation
GB/T 7714
Jiang, He Zhong,Quan, Xiao Fang,Tian, Wei Xi,et al. Fatty acid synthase inhibitors of phenolic constituents isolated from Garcinia mangostana[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2010,20(20):6045-6047.
APA Jiang, He Zhong.,Quan, Xiao Fang.,Tian, Wei Xi.,Hu, Jiang Miao.,Wang, Peng Cheng.,...&Zhao, You Xing.(2010).Fatty acid synthase inhibitors of phenolic constituents isolated from Garcinia mangostana.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,20(20),6045-6047.
MLA Jiang, He Zhong,et al."Fatty acid synthase inhibitors of phenolic constituents isolated from Garcinia mangostana".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 20.20(2010):6045-6047.
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