中国科学院昆明植物研究所机构知识库
Advanced  
KIB OpenIR  > 植物化学与西部植物资源持续利用国家重点实验室  > 期刊论文
题名: Fatty acid synthase inhibitors of phenolic constituents isolated from Garcinia mangostana
作者: Jiang, He Zhong2; Quan, Xiao Fang1; Tian, Wei Xi1; Hu, Jiang Miao2; Wang, Peng Cheng2; Huang, Sheng Zhuo2; Cheng, Zhong Quan2; Liang, Wen Juan2; Zhou, Jun2; Ma, Xiao Feng1; Zhao, You Xing2, 3
刊名: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
关键词: Fatty acid synthase (FAS) ; Garcinia mangostana ; Xanthone ; Benzophenone ; FAS inhibitors
英文摘要: Natural inhibitors of fatty acid synthase (FAS) are emerging as potential therapeutic agents to treat cancer and obesity. The bioassay-guided chemical investigation of the hulls of Garcinia mangostana led to the isolation of 13 phenolic compounds (1-13) mainly including xanthone and benzophenone, in which compounds 7, 8, 9, 10, and 11 were isolated from this plant for the first time and compound 9 was a new natural product. These isolates possess strong inhibitory activity of FAS with the IC(50) values ranging from 1.24 to 91.07 mu M. The study indicates that two types of natural products, xanthones and benzophenones, could be considered as promising FAS inhibitors. (c) 2010 Elsevier Ltd. All rights reserved.
出版日期: 2010-10-15
卷号: 20, 期号:20, 页码:6045-6047
DOI标识: 10.1016/j.bmcl.2010.08.061
语种: 英语
收录类别: SCI
学科分类: Chemistry, Medicinal; Chemistry, Organic
ISSN号: 0960-894X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/4144
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
201112280023.pdf(206KB)----开放获取--View Download

作者单位: 1.Chinese Acad Sci, Grad Univ, Coll Life Sci, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
3.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Haikou 571101, Peoples R China

Recommended Citation:
Jiang, HZ; Quan, XF; Tian, WX; Hu, JM; Wang, PC; Huang, SZ; Cheng, ZQ; Liang, WJ; Zhou, J; Ma, XF; Zhao, YX.Fatty acid synthase inhibitors of phenolic constituents isolated from Garcinia mangostana,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2010,20(20):6045-6047
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Jiang, He Zhong]'s Articles
[Quan, Xiao Fang]'s Articles
[Tian, Wei Xi]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Jiang, He Zhong]‘s Articles
[Quan, Xiao Fang]‘s Articles
[Tian, Wei Xi]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: 201112280023.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  中国科学院昆明植物研究所 - Feedback
Powered by CSpace