Fatty acid synthase inhibitors of phenolic constituents isolated from Garcinia mangostana
Jiang, He Zhong2; Quan, Xiao Fang1; Tian, Wei Xi1; Hu, Jiang Miao2; Wang, Peng Cheng2; Huang, Sheng Zhuo2; Cheng, Zhong Quan2; Liang, Wen Juan2; Zhou, Jun2; Ma, Xiao Feng1; Zhao, You Xing2,3
2010-10-15
发表期刊BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN0960-894X
卷号20期号:20页码:6045-6047
摘要Natural inhibitors of fatty acid synthase (FAS) are emerging as potential therapeutic agents to treat cancer and obesity. The bioassay-guided chemical investigation of the hulls of Garcinia mangostana led to the isolation of 13 phenolic compounds (1-13) mainly including xanthone and benzophenone, in which compounds 7, 8, 9, 10, and 11 were isolated from this plant for the first time and compound 9 was a new natural product. These isolates possess strong inhibitory activity of FAS with the IC(50) values ranging from 1.24 to 91.07 mu M. The study indicates that two types of natural products, xanthones and benzophenones, could be considered as promising FAS inhibitors. (c) 2010 Elsevier Ltd. All rights reserved.
关键词Fatty Acid Synthase (Fas) Garcinia Mangostana Xanthone Benzophenone Fas Inhibitors
资助信息Natural Science foundation of Yunnan [2008CD159]; National Natural Science foundation of China [30572252, 30670455]; GUCAS [O95101PY00]; K.C.Wong Education Foundation, Hong Kong
学科领域Chemistry, Medicinal ; Chemistry, Organic
DOI10.1016/j.bmcl.2010.08.061
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy ; Chemistry
WOS类目Chemistry, Medicinal ; Chemistry, Organic
WOS记录号WOS:000281963700019
引用统计
被引频次:34[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/4144
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Grad Univ, Coll Life Sci, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
3.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Haikou 571101, Peoples R China
推荐引用方式
GB/T 7714
Jiang, He Zhong,Quan, Xiao Fang,Tian, Wei Xi,et al. Fatty acid synthase inhibitors of phenolic constituents isolated from Garcinia mangostana[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2010,20(20):6045-6047.
APA Jiang, He Zhong.,Quan, Xiao Fang.,Tian, Wei Xi.,Hu, Jiang Miao.,Wang, Peng Cheng.,...&Zhao, You Xing.(2010).Fatty acid synthase inhibitors of phenolic constituents isolated from Garcinia mangostana.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,20(20),6045-6047.
MLA Jiang, He Zhong,et al."Fatty acid synthase inhibitors of phenolic constituents isolated from Garcinia mangostana".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 20.20(2010):6045-6047.
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