Efficient synthesis of galactosylceramide analogues for iNKT cell stimulation
Wenlan Chen; Chengfeng Xia; Li Cai; Peng George Wanga
2010-07-01
发表期刊BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN0960-894X
卷号20期号:13页码:3859-3862
摘要Glycolipids are potential antigens for iNKT cells recognition and demonstrate important roles in both innate and adaptive immunity. However, the difficulties in the preparation of pure configuration defined glycolipids limit the exploration of their different profiles in activating iNKT cells. We report here a concise and stereospecific preparation of novel galactosylceramide analogues by oxime ligation. This strategy would provide an efficient way to generate varied glycolipid analogues with either synthetic or natural carbohydrates for biological evaluations. (c) 2010 Elsevier Ltd. All rights reserved.
关键词Nkt Cells Glycolipid Ceramide
资助信息Ohio State University ; NIH [R21AI083513]
学科领域Chemistry, Medicinal ; Chemistry, Organic
DOI10.1016/j.bmcl.2010.05.045
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy ; Chemistry
WOS类目Chemistry, Medicinal ; Chemistry, Organic
WOS记录号WOS:000278644700005
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被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/4142
专题植物化学与西部植物资源持续利用国家重点实验室
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Wenlan Chen,Chengfeng Xia,Li Cai,et al. Efficient synthesis of galactosylceramide analogues for iNKT cell stimulation[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2010,20(13):3859-3862.
APA Wenlan Chen,Chengfeng Xia,Li Cai,&Peng George Wanga.(2010).Efficient synthesis of galactosylceramide analogues for iNKT cell stimulation.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,20(13),3859-3862.
MLA Wenlan Chen,et al."Efficient synthesis of galactosylceramide analogues for iNKT cell stimulation".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 20.13(2010):3859-3862.
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