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题名: Efficient synthesis of galactosylceramide analogues for iNKT cell stimulation
作者: Wenlan Chen; Chengfeng Xia; Li Cai; Peng George Wanga
刊名: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
关键词: NKT cells ; Glycolipid ; Ceramide
英文摘要: Glycolipids are potential antigens for iNKT cells recognition and demonstrate important roles in both innate and adaptive immunity. However, the difficulties in the preparation of pure configuration defined glycolipids limit the exploration of their different profiles in activating iNKT cells. We report here a concise and stereospecific preparation of novel galactosylceramide analogues by oxime ligation. This strategy would provide an efficient way to generate varied glycolipid analogues with either synthetic or natural carbohydrates for biological evaluations. (c) 2010 Elsevier Ltd. All rights reserved.
出版日期: 2010-07-01
卷号: 20, 期号:13, 页码:3859-3862
DOI标识: 10.1016/j.bmcl.2010.05.045
语种: 英语
ISSN号: 0960-894X
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/4142
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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Recommended Citation:
Chen, WL; Xia, CF; Cai, L; Wang, PG.Efficient synthesis of galactosylceramide analogues for iNKT cell stimulation,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2010,20(13):3859-3862
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文件名: Bioorg Med Chem Lett 2010.20.3859.pdf
格式: Adobe PDF
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