Efficient synthesis of galactosylceramide analogues for iNKT cell stimulation

doi:10.1016/j.bmcl.2010.05.045

	Efficient synthesis of galactosylceramide analogues for iNKT cell stimulation
	Wenlan Chen; Chengfeng Xia; Li Cai; Peng George Wanga
	2010-07-01
发表期刊	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN	0960-894X
卷号	20 期号:13 页码:3859-3862
摘要	Glycolipids are potential antigens for iNKT cells recognition and demonstrate important roles in both innate and adaptive immunity. However, the difficulties in the preparation of pure configuration defined glycolipids limit the exploration of their different profiles in activating iNKT cells. We report here a concise and stereospecific preparation of novel galactosylceramide analogues by oxime ligation. This strategy would provide an efficient way to generate varied glycolipid analogues with either synthetic or natural carbohydrates for biological evaluations. (c) 2010 Elsevier Ltd. All rights reserved.
关键词	Nkt Cells Glycolipid Ceramide
学科领域	Chemistry, Medicinal ; Chemistry, Organic
DOI	10.1016/j.bmcl.2010.05.045
收录类别	SCI
语种	英语
WOS记录号	WOS:000278644700005
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/4142
专题	植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Wenlan Chen,Chengfeng Xia,Li Cai,et al. Efficient synthesis of galactosylceramide analogues for iNKT cell stimulation[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2010,20(13):3859-3862.
APA	Wenlan Chen,Chengfeng Xia,Li Cai,&Peng George Wanga.(2010).Efficient synthesis of galactosylceramide analogues for iNKT cell stimulation.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,20(13),3859-3862.
MLA	Wenlan Chen,et al."Efficient synthesis of galactosylceramide analogues for iNKT cell stimulation".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 20.13(2010):3859-3862.

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