Efficient synthesis of galactosylceramide analogues for iNKT cell stimulation
Wenlan Chen; Chengfeng Xia; Li Cai; Peng George Wanga
2010-07-01
Source PublicationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN0960-894X
Volume20Issue:13Pages:3859-3862
AbstractGlycolipids are potential antigens for iNKT cells recognition and demonstrate important roles in both innate and adaptive immunity. However, the difficulties in the preparation of pure configuration defined glycolipids limit the exploration of their different profiles in activating iNKT cells. We report here a concise and stereospecific preparation of novel galactosylceramide analogues by oxime ligation. This strategy would provide an efficient way to generate varied glycolipid analogues with either synthetic or natural carbohydrates for biological evaluations. (c) 2010 Elsevier Ltd. All rights reserved.
KeywordNkt Cells Glycolipid Ceramide
Subject AreaChemistry, Medicinal ; Chemistry, Organic
DOI10.1016/j.bmcl.2010.05.045
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy ; Chemistry
WOS SubjectChemistry, Medicinal ; Chemistry, Organic
WOS IDWOS:000278644700005
Citation statistics
Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/4142
Collection植物化学与西部植物资源持续利用国家重点实验室
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GB/T 7714
Wenlan Chen,Chengfeng Xia,Li Cai,et al. Efficient synthesis of galactosylceramide analogues for iNKT cell stimulation[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2010,20(13):3859-3862.
APA Wenlan Chen,Chengfeng Xia,Li Cai,&Peng George Wanga.(2010).Efficient synthesis of galactosylceramide analogues for iNKT cell stimulation.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,20(13),3859-3862.
MLA Wenlan Chen,et al."Efficient synthesis of galactosylceramide analogues for iNKT cell stimulation".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 20.13(2010):3859-3862.
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