Effects of spiramine T on antioxidant enzymatic activities and nitric oxide production in cerebral ischemia-reperfusion gerbils
Li, L; Shen, YM; Yang, XS; Wu, WL; Wang, BG; Chen, ZH; Hao, XJ
2002-07-19
发表期刊BRAIN RESEARCH
ISSN0006-8993
卷号944期号:1-2页码:205-209
摘要Spiramine T, an atisine-type diterpene alkaloid isolated from the Chinese herbal medicine Spiraea japonica var. acuta (Rosaceae), was shown to have neuroprotective effects on cerebral ischemia-reperfusion injury. In this study, the effects of spiramine T on antioxidant enzymes and nitric oxide production were evaluated in gerbils subjected to global forebrain ischemia (10 min) and reperfusion (5 days). Spiramine T (1.0 and 2.0 mg kg(-1) i.p.) markedly reduced the content of lipid peroxide (LPO), increased the glutathione peroxidase (GSH-PX) activity, and inhibited the increase of nitric oxidase (NOS) activity and nitric oxide production in the cortex during ischemia-reperfusion in gerbils. These results suggested that the neuroprotective effects of spiramine T were related to modulation of endogenous antioxidant enzymatic activities and reduction of the formation of nitric oxide. (C) 2002 Elsevier Science B.V. All rights reserved.
关键词Spiraea Japonica Var. Acuta Rosaceae Spiramine t Cerebral Ischemia-reperfusion Antioxidant Enzyme Nitric Oxide Synthase
收录类别SCI
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/4132
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, Lab Phytochem, Kunming 650204, Yunnan, Peoples R China
2.Kunming Med Coll, Yunnan Pharmacol Labs Nat Prod, Kunming 650031, Yunnan, Peoples R China
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Li, L,Shen, YM,Yang, XS,et al. Effects of spiramine T on antioxidant enzymatic activities and nitric oxide production in cerebral ischemia-reperfusion gerbils[J]. BRAIN RESEARCH,2002,944(1-2):205-209.
APA Li, L.,Shen, YM.,Yang, XS.,Wu, WL.,Wang, BG.,...&Hao, XJ.(2002).Effects of spiramine T on antioxidant enzymatic activities and nitric oxide production in cerebral ischemia-reperfusion gerbils.BRAIN RESEARCH,944(1-2),205-209.
MLA Li, L,et al."Effects of spiramine T on antioxidant enzymatic activities and nitric oxide production in cerebral ischemia-reperfusion gerbils".BRAIN RESEARCH 944.1-2(2002):205-209.
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