Effects of spiramine T on antioxidant enzymatic activities and nitric oxide production in cerebral ischemia-reperfusion gerbils
Li, L; Shen, YM; Yang, XS; Wu, WL; Wang, BG; Chen, ZH; Hao, XJ
2002-07-19
Source PublicationBRAIN RESEARCH
ISSN0006-8993
Volume944Issue:1-2Pages:205-209
AbstractSpiramine T, an atisine-type diterpene alkaloid isolated from the Chinese herbal medicine Spiraea japonica var. acuta (Rosaceae), was shown to have neuroprotective effects on cerebral ischemia-reperfusion injury. In this study, the effects of spiramine T on antioxidant enzymes and nitric oxide production were evaluated in gerbils subjected to global forebrain ischemia (10 min) and reperfusion (5 days). Spiramine T (1.0 and 2.0 mg kg(-1) i.p.) markedly reduced the content of lipid peroxide (LPO), increased the glutathione peroxidase (GSH-PX) activity, and inhibited the increase of nitric oxidase (NOS) activity and nitric oxide production in the cortex during ischemia-reperfusion in gerbils. These results suggested that the neuroprotective effects of spiramine T were related to modulation of endogenous antioxidant enzymatic activities and reduction of the formation of nitric oxide. (C) 2002 Elsevier Science B.V. All rights reserved.
KeywordSpiraea Japonica Var. Acuta Rosaceae Spiramine t Cerebral Ischemia-reperfusion Antioxidant Enzyme Nitric Oxide Synthase
Subject AreaNeurosciences
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000177224100023
Citation statistics
Cited Times:24[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/4132
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, Lab Phytochem, Kunming 650204, Yunnan, Peoples R China
2.Kunming Med Coll, Yunnan Pharmacol Labs Nat Prod, Kunming 650031, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Li, L,Shen, YM,Yang, XS,et al. Effects of spiramine T on antioxidant enzymatic activities and nitric oxide production in cerebral ischemia-reperfusion gerbils[J]. BRAIN RESEARCH,2002,944(1-2):205-209.
APA Li, L.,Shen, YM.,Yang, XS.,Wu, WL.,Wang, BG.,...&Hao, XJ.(2002).Effects of spiramine T on antioxidant enzymatic activities and nitric oxide production in cerebral ischemia-reperfusion gerbils.BRAIN RESEARCH,944(1-2),205-209.
MLA Li, L,et al."Effects of spiramine T on antioxidant enzymatic activities and nitric oxide production in cerebral ischemia-reperfusion gerbils".BRAIN RESEARCH 944.1-2(2002):205-209.
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