Triterpenoid Alkaloids from Buxus microphylla
Yan, Yu-Xin1,2; Chen, Jian-Chao1; Sun, Yun1,2; Wang, Yuan-Yuan1; Su, Jia1; Li, Yan1; Qiu, Ming-Hua1
AbstractTwo new triterpenoid alkaloids, buxmicrophyllines J and K (1 and 2, resp.), together with four analogues, 3-6, were isolated from the leaves and stems of Buxus microphylla. The structures of the new compounds were elucidated by NMR and MS spectroscopic analyses. The partial assignments of the NMR spectra of 3 were also revised. Compounds 1 and 3-6 were evaluated for their growth inhibitory activity against human cell lines HL-60, SMMC-7721, A-549, SK-BR-3, and PANC-1. Compound 6 showed significant cytotoxicity against HL-60). SK-BR-3, and PANC-1 cell lines, with IC(50) values of 6.46, 19.61, and 28.57 mu m, respectively.
KeywordCycloeucalenol Interrelation Configuration Cyclobuxine Hyrcana
Subject AreaBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
Indexed BySCI
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000280613000015
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Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Yan, Yu-Xin,Chen, Jian-Chao,Sun, Yun,et al. Triterpenoid Alkaloids from Buxus microphylla[J]. CHEMISTRY & BIODIVERSITY,2010,7(7):1822-1827.
APA Yan, Yu-Xin.,Chen, Jian-Chao.,Sun, Yun.,Wang, Yuan-Yuan.,Su, Jia.,...&Qiu, Ming-Hua.(2010).Triterpenoid Alkaloids from Buxus microphylla.CHEMISTRY & BIODIVERSITY,7(7),1822-1827.
MLA Yan, Yu-Xin,et al."Triterpenoid Alkaloids from Buxus microphylla".CHEMISTRY & BIODIVERSITY 7.7(2010):1822-1827.
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