| Antituberculosis Agents and an Inhibitor of the para-Aminobenzoic Acid Biosynthetic Pathway from Hydnocarpus anthelminthica Seeds | |
Wang, Jun-Feng1,3; Dai, Huan-Qin2; Wei, Yu-Ling4; Zhu, Hua-Jie1; Yan, Yong-Ming1; Wang, Yue-Hu1 ; Long, Chun-Lin1; Zhong, Hui-Min3; Zhang, Li-Xin2; Cheng, Yong-Xian1
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| 2010 | |
| 发表期刊 | CHEMISTRY & BIODIVERSITY
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| ISSN | 1612-1872 |
| 卷号 | 7期号:8页码:2046-2053 |
| 摘要 | Investigation on the extracts of Hydnocarpus anthelminthica seeds led to the isolation of three new compounds, anthelminthieins A C (1-3, resp). and two known ones, namely chaulmoogric acid (4) and ethyl chaulmoograte (5) Their structures were determined mainly by using spectroscopic techniques The absolute configuration at the cyclopentenyl moiety of compound 2 was rationalized by quantum calculations Base hydrolysis, followed by optical-rotation comparison, allowed assignment of the configuration of chaulmoogric-acid moiety of compounds 3 and 5 Biological assays revealed that compounds 1-5 significantly inhibit Mycobacterium tuberculosis(MTB) growth with MIC values of 5 54. 16 70, 4 38, 9 82, and 16 80 mu M, respectively Compound 3 was found to inhibit the pathway between chorismate and para-aminobenzoic acid (pAba) with a MIC value of 11 3 mu m, representing a new example of pAba inhibitor isolated from a natural source All compounds were not toxic to Candida albicans SC5314 at a concentration up to 100 mu m |
| 关键词 | Multidrug-resistant Natural-products Wightiana Flavonolignans Tuberculosis |
| 学科领域 | Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000281489400016 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/4058 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Inst Microbiol, Beijing, Peoples R China 3.Qingdao Univ Sci & Technol, Coll Chem & Mol Engn, Qingdao, Peoples R China 4.Yunnan Acad Tobacco Sci, Kunming, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Jun-Feng,Dai, Huan-Qin,Wei, Yu-Ling,et al. Antituberculosis Agents and an Inhibitor of the para-Aminobenzoic Acid Biosynthetic Pathway from Hydnocarpus anthelminthica Seeds[J]. CHEMISTRY & BIODIVERSITY,2010,7(8):2046-2053. |
| APA | Wang, Jun-Feng.,Dai, Huan-Qin.,Wei, Yu-Ling.,Zhu, Hua-Jie.,Yan, Yong-Ming.,...&Cheng, Yong-Xian.(2010).Antituberculosis Agents and an Inhibitor of the para-Aminobenzoic Acid Biosynthetic Pathway from Hydnocarpus anthelminthica Seeds.CHEMISTRY & BIODIVERSITY,7(8),2046-2053. |
| MLA | Wang, Jun-Feng,et al."Antituberculosis Agents and an Inhibitor of the para-Aminobenzoic Acid Biosynthetic Pathway from Hydnocarpus anthelminthica Seeds".CHEMISTRY & BIODIVERSITY 7.8(2010):2046-2053. |
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