Antituberculosis Agents and an Inhibitor of the para-Aminobenzoic Acid Biosynthetic Pathway from Hydnocarpus anthelminthica Seeds
Wang, Jun-Feng1,3; Dai, Huan-Qin2; Wei, Yu-Ling4; Zhu, Hua-Jie1; Yan, Yong-Ming1; Wang, Yue-Hu1; Long, Chun-Lin1; Zhong, Hui-Min3; Zhang, Li-Xin2; Cheng, Yong-Xian1
2010
发表期刊CHEMISTRY & BIODIVERSITY
ISSN1612-1872
卷号7期号:8页码:2046-2053
摘要Investigation on the extracts of Hydnocarpus anthelminthica seeds led to the isolation of three new compounds, anthelminthieins A C (1-3, resp). and two known ones, namely chaulmoogric acid (4) and ethyl chaulmoograte (5) Their structures were determined mainly by using spectroscopic techniques The absolute configuration at the cyclopentenyl moiety of compound 2 was rationalized by quantum calculations Base hydrolysis, followed by optical-rotation comparison, allowed assignment of the configuration of chaulmoogric-acid moiety of compounds 3 and 5 Biological assays revealed that compounds 1-5 significantly inhibit Mycobacterium tuberculosis(MTB) growth with MIC values of 5 54. 16 70, 4 38, 9 82, and 16 80 mu M, respectively Compound 3 was found to inhibit the pathway between chorismate and para-aminobenzoic acid (pAba) with a MIC value of 11 3 mu m, representing a new example of pAba inhibitor isolated from a natural source All compounds were not toxic to Candida albicans SC5314 at a concentration up to 100 mu m
关键词Multidrug-resistant Natural-products Wightiana Flavonolignans Tuberculosis
资助信息Chinese Academy of Sciences ; Talent Scholarship of Yunnan Youth [2007PY01-48]; National Natural Science Foundation of China [30901849]; Ministry of Science and Technology of China [2008ZX09401-004]; MOST [2007DFB31620]; 863 Hi-Tech Research and Development Program of China [2006AA09Z402, 2007AA09Z443]; Hundred Talents Program
学科领域Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
收录类别SCI
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
WOS类目Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS记录号WOS:000281489400016
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/4058
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Inst Microbiol, Beijing, Peoples R China
3.Qingdao Univ Sci & Technol, Coll Chem & Mol Engn, Qingdao, Peoples R China
4.Yunnan Acad Tobacco Sci, Kunming, Peoples R China
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Wang, Jun-Feng,Dai, Huan-Qin,Wei, Yu-Ling,et al. Antituberculosis Agents and an Inhibitor of the para-Aminobenzoic Acid Biosynthetic Pathway from Hydnocarpus anthelminthica Seeds[J]. CHEMISTRY & BIODIVERSITY,2010,7(8):2046-2053.
APA Wang, Jun-Feng.,Dai, Huan-Qin.,Wei, Yu-Ling.,Zhu, Hua-Jie.,Yan, Yong-Ming.,...&Cheng, Yong-Xian.(2010).Antituberculosis Agents and an Inhibitor of the para-Aminobenzoic Acid Biosynthetic Pathway from Hydnocarpus anthelminthica Seeds.CHEMISTRY & BIODIVERSITY,7(8),2046-2053.
MLA Wang, Jun-Feng,et al."Antituberculosis Agents and an Inhibitor of the para-Aminobenzoic Acid Biosynthetic Pathway from Hydnocarpus anthelminthica Seeds".CHEMISTRY & BIODIVERSITY 7.8(2010):2046-2053.
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