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题名: Antituberculosis Agents and an Inhibitor of the para-Aminobenzoic Acid Biosynthetic Pathway from Hydnocarpus anthelminthica Seeds
作者: Wang, Jun-Feng1, 3; Dai, Huan-Qin2; Wei, Yu-Ling4; Zhu, Hua-Jie1; Yan, Yong-Ming1; Wang, Yue-Hu1; Long, Chun-Lin1; Zhong, Hui-Min3; Zhang, Li-Xin2; null(程永现)1
刊名: CHEMISTRY & BIODIVERSITY
关键词: MULTIDRUG-RESISTANT ; NATURAL-PRODUCTS ; WIGHTIANA ; FLAVONOLIGNANS ; TUBERCULOSIS
英文摘要: Investigation on the extracts of Hydnocarpus anthelminthica seeds led to the isolation of three new compounds, anthelminthieins A C (1-3, resp). and two known ones, namely chaulmoogric acid (4) and ethyl chaulmoograte (5) Their structures were determined mainly by using spectroscopic techniques The absolute configuration at the cyclopentenyl moiety of compound 2 was rationalized by quantum calculations Base hydrolysis, followed by optical-rotation comparison, allowed assignment of the configuration of chaulmoogric-acid moiety of compounds 3 and 5 Biological assays revealed that compounds 1-5 significantly inhibit Mycobacterium tuberculosis(MTB) growth with MIC values of 5 54. 16 70, 4 38, 9 82, and 16 80 mu M, respectively Compound 3 was found to inhibit the pathway between chorismate and para-aminobenzoic acid (pAba) with a MIC value of 11 3 mu m, representing a new example of pAba inhibitor isolated from a natural source All compounds were not toxic to Candida albicans SC5314 at a concentration up to 100 mu m
出版日期: 2010
卷号: 7, 期号:8, 页码:2046-2053
语种: 英语
ISSN号: 1612-1872
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/4058
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Inst Microbiol, Beijing, Peoples R China
3.Qingdao Univ Sci & Technol, Coll Chem & Mol Engn, Qingdao, Peoples R China
4.Yunnan Acad Tobacco Sci, Kunming, Peoples R China

Recommended Citation:
Wang, JF; Dai, HQ; Wei, YL; Zhu, HJ; Yan, YM; Wang, YH; Long, CL; Zhong, HM; Zhang, LX; Cheng, YX.Antituberculosis Agents and an Inhibitor of the para-Aminobenzoic Acid Biosynthetic Pathway from Hydnocarpus anthelminthica Seeds,CHEMISTRY & BIODIVERSITY,2010,7(8):2046-2053
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