6,7-seco-ent-Kaurane Diterpenoids from Isodon sculponeatus with Cytotoxic Activity

	6,7-seco-ent-Kaurane Diterpenoids from Isodon sculponeatus with Cytotoxic Activity
	Lia, Xian 1,2; Pu, Jian-Xin1 ; Weng, Zhi-Ying 1,2; Zhao, Yu 1; Zhao, Yong 1; Xiao, Wei-Lie 1; Sun, Han-Dong1
	2010-12-01
发表期刊	CHEMISTRY & BIODIVERSITY
ISSN	1612-1872
卷号	7 期号:12 页码:2888-2896
摘要	Six new 6,7-seco-ent-kaurane diterpenoids, sculponeatins N-S (1-6, resp.), together with eleven known analogues, 7-17, were isolated from the aerial parts of Isodon sculponeatus. The structures of compounds 1-6 were elucidated by spectroscopic methods including extensive ID- and 2D-NMR experiments, as well as HR-ESI-MS analysis. All diterpenoids obtained were assayed for their cytotoxic activity against K562 and HepG2 human tumor cell lines. Among them, compound 1 showed the most significant cytotoxicity with the IC(50) values of 0.21 and 0.29 mu M, respectively. The structure-activity relationships are discussed.
关键词	Absolute Configuration Rabdosia-longituba Terpenoids Japonicus
学科领域	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
收录类别	SCI
语种	英语
WOS记录号	WOS:000285393800007
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/4056
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Kunming Med Coll, Sch Pharm, Kunming 650031, Peoples R China
推荐引用方式 GB/T 7714	Lia, Xian,Pu, Jian-Xin,Weng, Zhi-Ying,et al. 6,7-seco-ent-Kaurane Diterpenoids from Isodon sculponeatus with Cytotoxic Activity[J]. CHEMISTRY & BIODIVERSITY,2010,7(12):2888-2896.
APA	Lia, Xian.,Pu, Jian-Xin.,Weng, Zhi-Ying.,Zhao, Yu.,Zhao, Yong.,...&Sun, Han-Dong.(2010).6,7-seco-ent-Kaurane Diterpenoids from Isodon sculponeatus with Cytotoxic Activity.CHEMISTRY & BIODIVERSITY,7(12),2888-2896.
MLA	Lia, Xian,et al."6,7-seco-ent-Kaurane Diterpenoids from Isodon sculponeatus with Cytotoxic Activity".CHEMISTRY & BIODIVERSITY 7.12(2010):2888-2896.

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