6,7-seco-ent-Kaurane Diterpenoids from Isodon sculponeatus with Cytotoxic Activity
Lia, Xian1,2; Pu, Jian-Xin1; Weng, Zhi-Ying1,2; Zhao, Yu1; Zhao, Yong1; Xiao, Wei-Lie1; Sun, Han-Dong1
2010-12-01
发表期刊CHEMISTRY & BIODIVERSITY
ISSN1612-1872
卷号7期号:12页码:2888-2896
摘要Six new 6,7-seco-ent-kaurane diterpenoids, sculponeatins N-S (1-6, resp.), together with eleven known analogues, 7-17, were isolated from the aerial parts of Isodon sculponeatus. The structures of compounds 1-6 were elucidated by spectroscopic methods including extensive ID- and 2D-NMR experiments, as well as HR-ESI-MS analysis. All diterpenoids obtained were assayed for their cytotoxic activity against K562 and HepG2 human tumor cell lines. Among them, compound 1 showed the most significant cytotoxicity with the IC(50) values of 0.21 and 0.29 mu M, respectively. The structure-activity relationships are discussed.
关键词Absolute Configuration Rabdosia-longituba Terpenoids Japonicus
资助信息NSFC [30772637]; NSFC-Joint Foundation of Yunnan Province [U0832602]; Major State Basic Research Development Program of China [2009CB522300, 2009CB940900]; Natural Science Foundation of Yunnan Province [2008CD162]; CAS [KSCX2-YW-R-25]
收录类别SCI
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/4056
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Kunming Med Coll, Sch Pharm, Kunming 650031, Peoples R China
推荐引用方式
GB/T 7714
Lia, Xian,Pu, Jian-Xin,Weng, Zhi-Ying,et al. 6,7-seco-ent-Kaurane Diterpenoids from Isodon sculponeatus with Cytotoxic Activity[J]. CHEMISTRY & BIODIVERSITY,2010,7(12):2888-2896.
APA Lia, Xian.,Pu, Jian-Xin.,Weng, Zhi-Ying.,Zhao, Yu.,Zhao, Yong.,...&Sun, Han-Dong.(2010).6,7-seco-ent-Kaurane Diterpenoids from Isodon sculponeatus with Cytotoxic Activity.CHEMISTRY & BIODIVERSITY,7(12),2888-2896.
MLA Lia, Xian,et al."6,7-seco-ent-Kaurane Diterpenoids from Isodon sculponeatus with Cytotoxic Activity".CHEMISTRY & BIODIVERSITY 7.12(2010):2888-2896.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
201112280067.pdf(235KB) 开放获取--请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Lia, Xian]的文章
[Pu, Jian-Xin]的文章
[Weng, Zhi-Ying]的文章
百度学术
百度学术中相似的文章
[Lia, Xian]的文章
[Pu, Jian-Xin]的文章
[Weng, Zhi-Ying]的文章
必应学术
必应学术中相似的文章
[Lia, Xian]的文章
[Pu, Jian-Xin]的文章
[Weng, Zhi-Ying]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。