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题名: 6,7-seco-ent-Kaurane Diterpenoids from Isodon sculponeatus with Cytotoxic Activity
作者: Lia, Xian1, 2; Pu, Jian-Xin1; Weng, Zhi-Ying1, 2; Zhao, Yu1; Zhao, Yong1; Xiao, Wei-Lie1; null(孙汉董)1
刊名: CHEMISTRY & BIODIVERSITY
关键词: ABSOLUTE CONFIGURATION ; RABDOSIA-LONGITUBA ; TERPENOIDS ; JAPONICUS
英文摘要: Six new 6,7-seco-ent-kaurane diterpenoids, sculponeatins N-S (1-6, resp.), together with eleven known analogues, 7-17, were isolated from the aerial parts of Isodon sculponeatus. The structures of compounds 1-6 were elucidated by spectroscopic methods including extensive ID- and 2D-NMR experiments, as well as HR-ESI-MS analysis. All diterpenoids obtained were assayed for their cytotoxic activity against K562 and HepG2 human tumor cell lines. Among them, compound 1 showed the most significant cytotoxicity with the IC(50) values of 0.21 and 0.29 mu M, respectively. The structure-activity relationships are discussed.
出版日期: 2010-12-01
卷号: 7, 期号:12, 页码:2888-2896
语种: 英语
ISSN号: 1612-1872
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/4056
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Kunming Med Coll, Sch Pharm, Kunming 650031, Peoples R China

Recommended Citation:
Lia, XA; Pu, JX; Weng, ZY; Zhao, Y; Zhao, Y; Xiao, WL; Sun, HD.6,7-seco-ent-Kaurane Diterpenoids from Isodon sculponeatus with Cytotoxic Activity,CHEMISTRY & BIODIVERSITY,2010,7(12):2888-2896
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