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题名: Norlignans from Sequoia sempervirens
作者: Zhang, YM; Tan, NH; Yang, YB; Lu, Y; Cao, P; Wu, YS
刊名: CHEMISTRY & BIODIVERSITY
关键词: TAIWANIA-CRYPTOMERIOIDES
英文摘要: Six new norlignans, named sequosempervirins B-G (1-6), together with three known norlignans, agatharesinol (7), agatharesinol acetonide (8), and sugiresinol (9), were isolated from the branches and leaves of Sequoia sempervirens. Their structures were determined mainly by high-resolution mass spectroscopy (HRMS), and various 1D- and 2D-NMR methods, as well as, in the case of 1, by means of X-ray diffraction. Compound 8 showed anticancer activity towards the A549 non-small-cell lung-cancer cell line (IC50 = 27.1 mu m). The acetone extract of S. sempervirens was found to be antifungal towards Candida glabrata (IC50 = 15.98 mu g/ml), and both the acetone and MeOH extracts inhibited the proteolytic activity of cathepsin B (IC50 = 4.58 and 5.49 mu g/ml, resp.).
出版日期: 2005
卷号: 2, 期号:4, 页码:497-505
语种: 英语
ISSN号: 1612-1872
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/4048
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
3.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
4.Peking Union Med Coll, Beijing 100050, Peoples R China

Recommended Citation:
Zhang, YM; Tan, NH; Yang, YB; Lu, Y; Cao, P; Wu, YS.Norlignans from Sequoia sempervirens,CHEMISTRY & BIODIVERSITY,2005,2(4):497-505
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