Norlignans from Sequoia sempervirens

	Norlignans from Sequoia sempervirens
	Zhang, YM ; Tan, NH ; Yang, YB ; Lu, Y ; Cao, P ; Wu, YS
	2005
发表期刊	CHEMISTRY & BIODIVERSITY
ISSN	1612-1872
卷号	2 期号:4 页码:497-505
摘要	Six new norlignans, named sequosempervirins B-G (1-6), together with three known norlignans, agatharesinol (7), agatharesinol acetonide (8), and sugiresinol (9), were isolated from the branches and leaves of Sequoia sempervirens. Their structures were determined mainly by high-resolution mass spectroscopy (HRMS), and various 1D- and 2D-NMR methods, as well as, in the case of 1, by means of X-ray diffraction. Compound 8 showed anticancer activity towards the A549 non-small-cell lung-cancer cell line (IC50 = 27.1 mu m). The acetone extract of S. sempervirens was found to be antifungal towards Candida glabrata (IC50 = 15.98 mu g/ml), and both the acetone and MeOH extracts inhibited the proteolytic activity of cathepsin B (IC50 = 4.58 and 5.49 mu g/ml, resp.).
关键词	Taiwania-cryptomerioides
学科领域	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
收录类别	SCI
语种	英语
WOS记录号	WOS:000228770000008
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/4048
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China 4.Peking Union Med Coll, Beijing 100050, Peoples R China
推荐引用方式 GB/T 7714	Zhang, YM,Tan, NH,Yang, YB,et al. Norlignans from Sequoia sempervirens[J]. CHEMISTRY & BIODIVERSITY,2005,2(4):497-505.
APA	Zhang, YM,Tan, NH,Yang, YB,Lu, Y,Cao, P,&Wu, YS.(2005).Norlignans from Sequoia sempervirens.CHEMISTRY & BIODIVERSITY,2(4),497-505.
MLA	Zhang, YM,et al."Norlignans from Sequoia sempervirens".CHEMISTRY & BIODIVERSITY 2.4(2005):497-505.

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