Small Compound 6-O-Angeloylplenolin Induces Mitotic Arrest and Exhibits Therapeutic Potentials in Multiple Myeloma
Liu, Ying1,2,3; Chen, Xiao-Qin4; Liang, Heng-Xing5; Zhang, Feng-Xiang1,2; Zhang, Bo1,2; Jin, Jie6; Chen, Yong-Long1,2; Cheng, Yong-Xian5; Zhou, Guang-Biao1,2
2011-07-06
发表期刊PLOS ONE
ISSN1932-6203
卷号6期号:7页码:e21930
摘要Background: Multiple myeloma (MM) is a disease of cell cycle dysregulation while cell cycle modulation can be a target for MM therapy. In this study we investigated the effects and mechanisms of action of a sesquiterpene lactone 6-O-angeloylplenolin (6-OAP) on MM cells.
关键词Nf-kappa-b Cell-cycle Control Overcomes Drug-resistance Centipeda-minima Antitumor-activity Kinase-activity Human Cancer In-vitro Activation Expression
资助信息National Key Program for Basic Research (973)[2010CB529201]; CAS[KSCX1-YW-R-26, KSCX2-YW-R-235]; National Natural Science Foundation of China[81071930, 30871110]; National Major Scientific and Technological Program for Drug Discovery[2009ZX09103-101]; Natural Science Foundation of Yunnan[2006B0041Q]; Talent Scholarship for the Youth of Yunnan[2007PY01-48]
学科领域Biology
DOI10.1371/journal.pone.0021930
收录类别SCI
语种英语
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000292632000037
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/3966
专题中国科学院东亚植物多样性与生物地理学重点实验室
作者单位1.Chinese Acad Sci, Inst Zool, Guangzhou Inst Biomed & Hlth, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Zool, State Key Lab Biomembrane & Membrane Biotechnol, Beijing, Peoples R China
3.Univ Sci & Technol China, Sch Life Sci, Hefei 230026, Peoples R China
4.Sun Yat Sen Univ, Canc Hosp, Dept Hematol, Guangzhou 510275, Guangdong, Peoples R China
5.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming, Peoples R China
6.Zhejiang Univ, Coll Med, Affiliated Hosp 1, Dept Hematol, Hangzhou 310003, Zhejiang, Peoples R China
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Liu, Ying,Chen, Xiao-Qin,Liang, Heng-Xing,et al. Small Compound 6-O-Angeloylplenolin Induces Mitotic Arrest and Exhibits Therapeutic Potentials in Multiple Myeloma[J]. PLOS ONE,2011,6(7):e21930.
APA Liu, Ying.,Chen, Xiao-Qin.,Liang, Heng-Xing.,Zhang, Feng-Xiang.,Zhang, Bo.,...&Zhou, Guang-Biao.(2011).Small Compound 6-O-Angeloylplenolin Induces Mitotic Arrest and Exhibits Therapeutic Potentials in Multiple Myeloma.PLOS ONE,6(7),e21930.
MLA Liu, Ying,et al."Small Compound 6-O-Angeloylplenolin Induces Mitotic Arrest and Exhibits Therapeutic Potentials in Multiple Myeloma".PLOS ONE 6.7(2011):e21930.
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