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New ursane-type triterpenoids from Clerodendranthus spicatus 期刊论文
FITOTERAPIA, 2017, 卷号: 119, 页码: 69-74
作者:  Luo, Yong;  Cheng, Li-Zhi;  Luo, Qi;  Yan, Yong-Ming;  Wang, Shu-Mei;  Sun, Qin;  Cheng, Yong-Xian
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Clerodendranthus Spicatus  Ursane-type Triterpenoids  Human Cancer Cells  Kidney Fibroblast Cells  
Cheliensisin A (Chel A) induces apoptosis in human bladder cancer cells by promoting PHLPP2 protein degradation 期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 41, 页码: 66689-66699
作者:  Zhang, Ruowen;  Che, Xun;  Zhang, Jingjie;  Li, Yang;  Li, Jingxia;  Deng, Xu;  Zhu, Junlan;  Jin, Honglei;  Zhao, Qinshi;  Huang, Chuanshu
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Chel a  Human Bladder Cancer  Apoptosis  Phlpp2  C-jun  
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:  Zeng, Guang-Zhi;  Fan, Jun-Ting;  Xu, Jun-Ju;  Li, Yan;  Tan, Ning-Hua
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One Of The Major compOnents Isolated From The Traditional  2-methyl-1  Chinese Medicine Rubia Yunnanensis  3  Exhibited Inhibitory Activity On The proliferatiOn Of Several  6-trihydroxy-9  HumAn CAncer Cell Lines. The Results From An Annexin V-fitc (fluoresein-5-isothiocyAnate) Apoptosis Assay  10-anthraquinone (Mta)  And Dna Content Analysis Showed That Mta Exerted Cytotoxicity Via Apoptosis Induction And G2/m Cell Cycle  Arrest In Human Cervical carcInoma Hela Cells. Further  Mta Was Found To Induce apopTosis Of Hela Cells  Through The MITochondria-mediated Pathway. It Caused The Translocation Of Bax To The mITochondria And  Release Of Cytochrome c Into The Cytosol  Which Caused The Cleavage Of Caspase And Poly(Adp-ribose)  Polymerase And Finally Triggered The Apoptosis. furThermore  The P53/p21/cdc2-cyclin B1 Signaling Was  Found Related To The G2/m Arrest Caused By Mta. The Over-expression Of P21 And Down-expression Of  Cyclin B1 Caused By Mta Inactivated The cdc2-Cyclin B1 Complex Of G2/m Checkpoint And Finally Caused  The G2/m Arrest In Hela Cells. ThIs Study Demonstrated That Mta Is a Potential Anti-cancer Component Of  R. Yunnanensis  a Folk Anti-cancer Herb Used In Yunnan  China.  
Small Compound 6-O-Angeloylplenolin Induces Mitotic Arrest and Exhibits Therapeutic Potentials in Multiple Myeloma 期刊论文
PLOS ONE, 2011, 卷号: 6, 期号: 7, 页码: e21930
作者:  Liu, Ying;  Chen, Xiao-Qin;  Liang, Heng-Xing;  Zhang, Feng-Xiang;  Zhang, Bo;  Jin, Jie;  Chen, Yong-Long;  Cheng, Yong-Xian;  Zhou, Guang-Biao
Adobe PDF(877Kb)  |  收藏  |  浏览/下载：426/114  |  提交时间：2012/03/16
Nf-kappa-b  Cell-cycle Control  Overcomes Drug-resistance  Centipeda-minima  Antitumor-activity  Kinase-activity  Human Cancer  In-vitro  Activation  Expression  
Megathyrin B: A cytotoxic diterpene from Isodon megathyrsus 期刊论文
PLANTA MEDICA, 1998, 卷号: 64, 期号: 8, 页码: 728-731
作者:  Qiu, SX;  Sun, HD;  Lobkovsky, E;  Chai, H;  Clardy, I;  Farnsworth, NR;  Pezzuto, JM;  Fong, HHS
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Isodon Megathyrsus  Labiatae  Leaves  Ent-kaurene Diterpene  Human Cancer Lines  Cytotoxic Activity  2d-nmr Techniques  X-ray Crystallography  Megathyrin b  Electrospray Lc/ms