Antiviral activity and possible mechanisms of action of pentagalloylglucose (PGG) against influenza A virus
Liu, Ge1; Xiong, Sheng1,2; Xiang, Yang-Fei2; Guo, Chao-Wan1; Ge, Feng1; Yang, Chong-Ren3; Zhang, Ying-Jun3; Wang, Yi-Fei2; Kitazato, Kaio1
2011-08-01
发表期刊ARCHIVES OF VIROLOGY
ISSN0304-8608
卷号156期号:8页码:1359-1369
摘要Influenza A virus (IAV) infection is a major public health threat leading to significant morbidity and mortality. The emergence of drug-resistant virus strains highlights the urgent need to develop novel antiviral drugs with alternative modes of action. Pentagalloylglucose (PGG), a naturally occurring polyphenolic compound, possesses a broad spectrum of biological activities. In this study, we found that PGG has anti-influenza-virus activity, and investigated its possible mechanism(s) of action in vitro. Both pre-incubation of virus prior to infection and post-exposure of infected cells with PGG significantly inhibited virus yields. Influenza-virus-induced hemagglutination of chicken red blood cells was inhibited by PGG treatment, suggesting that PGG can inhibit IAV infection by interacting with the viral hemagglutinin. PGG did not affect viral protein synthesis or nuclear transport of viral nucleoprotein (NP) but greatly reduced plasma membrane accumulation of NP protein at the late stage of the replication cycle. Furthermore, PGG significantly reduced virus budding and progeny virus release from infected cells. This study revealed for the first time that PGG can inhibit IAV replication with a dual mode of action and offers new insights into its underlying mechanisms of antiviral action.
关键词H1n1 Virus 1 Kappa-b 2 Inhibition 3 Infection 4 6-penta-o-galloyl-beta-d-glucose Cells Plant H5n1 Replication Propagation
资助信息Tokyo Biochemical Research Foundation; National Science Foundation of China[U0632010]; State Key Laboratory of Phytochemistry and Plant Resources in West China; Kunming Institute of Botany; Chinese Academy of Sciences[P2008-KF07, P2008-ZZ08]
学科领域Virology
DOI10.1007/s00705-011-0989-9
收录类别SCI
语种英语
WOS研究方向Virology
WOS类目Virology
WOS记录号WOS:000293236100006
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被引频次:31[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/3930
专题中国科学院东亚植物多样性与生物地理学重点实验室
作者单位1.Nagasaki Univ, Grad Sch Biomed Sci, Div Mol Pharmacol Infect agents, Dept Mol Microbiol & Immunol, Nagasaki 8528521, Japan
2.Jinan Univ, Biomed R&D Ctr, Natl Engn Res Ctr Genet Med, Guangdong Prov Key Lab Bioengn Med, Guangzhou 510632, Guangdong, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
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Liu, Ge,Xiong, Sheng,Xiang, Yang-Fei,et al. Antiviral activity and possible mechanisms of action of pentagalloylglucose (PGG) against influenza A virus[J]. ARCHIVES OF VIROLOGY,2011,156(8):1359-1369.
APA Liu, Ge.,Xiong, Sheng.,Xiang, Yang-Fei.,Guo, Chao-Wan.,Ge, Feng.,...&Kitazato, Kaio.(2011).Antiviral activity and possible mechanisms of action of pentagalloylglucose (PGG) against influenza A virus.ARCHIVES OF VIROLOGY,156(8),1359-1369.
MLA Liu, Ge,et al."Antiviral activity and possible mechanisms of action of pentagalloylglucose (PGG) against influenza A virus".ARCHIVES OF VIROLOGY 156.8(2011):1359-1369.
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