中国科学院昆明植物研究所机构知识库
Advanced  
KIB OpenIR  > 中国科学院东亚植物多样性与生物地理学重点实验室  > 期刊论文
题名: Antiviral activity and possible mechanisms of action of pentagalloylglucose (PGG) against influenza A virus
作者: Liu, Ge1; Xiong, Sheng1, 2; Xiang, Yang-Fei2; Guo, Chao-Wan1; Ge, Feng1; Yang, Chong-Ren3; null(张颖君)3; Wang, Yi-Fei2; Kitazato, Kaio1
刊名: ARCHIVES OF VIROLOGY
关键词: H1N1 VIRUS ; 1 ; KAPPA-B ; 2 ; INHIBITION ; 3 ; INFECTION ; 4 ; 6-PENTA-O-GALLOYL-BETA-D-GLUCOSE ; CELLS ; PLANT ; H5N1 ; REPLICATION ; PROPAGATION
英文摘要: Influenza A virus (IAV) infection is a major public health threat leading to significant morbidity and mortality. The emergence of drug-resistant virus strains highlights the urgent need to develop novel antiviral drugs with alternative modes of action. Pentagalloylglucose (PGG), a naturally occurring polyphenolic compound, possesses a broad spectrum of biological activities. In this study, we found that PGG has anti-influenza-virus activity, and investigated its possible mechanism(s) of action in vitro. Both pre-incubation of virus prior to infection and post-exposure of infected cells with PGG significantly inhibited virus yields. Influenza-virus-induced hemagglutination of chicken red blood cells was inhibited by PGG treatment, suggesting that PGG can inhibit IAV infection by interacting with the viral hemagglutinin. PGG did not affect viral protein synthesis or nuclear transport of viral nucleoprotein (NP) but greatly reduced plasma membrane accumulation of NP protein at the late stage of the replication cycle. Furthermore, PGG significantly reduced virus budding and progeny virus release from infected cells. This study revealed for the first time that PGG can inhibit IAV replication with a dual mode of action and offers new insights into its underlying mechanisms of antiviral action.
出版日期: 2011-08-01
卷号: 156, 期号:8, 页码:1359-1369
DOI标识: 10.1007/s00705-011-0989-9
语种: 英语
ISSN号: 0304-8608
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/3930
Appears in Collections:中国科学院东亚植物多样性与生物地理学重点实验室_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
2012091106.pdf(712KB)----开放获取--View 联系获取全文

作者单位: 1.Nagasaki Univ, Grad Sch Biomed Sci, Div Mol Pharmacol Infect agents, Dept Mol Microbiol & Immunol, Nagasaki 8528521, Japan
2.Jinan Univ, Biomed R&D Ctr, Natl Engn Res Ctr Genet Med, Guangdong Prov Key Lab Bioengn Med, Guangzhou 510632, Guangdong, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China

Recommended Citation:
Liu, Ge; Xiong, Sheng; Xiang, Yang-Fei; Guo, Chao-Wan; Ge, Feng; Yang, Chong-Ren; Zhang, Ying-Jun; Wang, Yi-Fei; Kitazato, Kaio.Antiviral activity and possible mechanisms of action of pentagalloylglucose (PGG) against influenza A virus,ARCHIVES OF VIROLOGY,2011,156(8):1359-1369
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Liu, Ge]'s Articles
[Xiong, Sheng]'s Articles
[Xiang, Yang-Fei]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Liu, Ge]‘s Articles
[Xiong, Sheng]‘s Articles
[Xiang, Yang-Fei]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: 2012091106.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  中国科学院昆明植物研究所 - Feedback
Powered by CSpace