| Variation in Carbohydrates between Cancer and Normal Cell Membranes Revealed by Super-Resolution Fluorescence Imaging | |
Chen, Junling1,4; Liu, Tianzhou2; Gao, Jing1; Gao, Lan3,4; Zhou, Lulu1,4; Cai, Mingjun1; Shi, Yan1; Xiong, Wenyong3 ; Jiang, Junguang1; Tong, Ti2; Wang, Hongda1
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| 2016-12-01 | |
| 发表期刊 | ADVANCED SCIENCE
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| 卷号 | 3期号:12页码:1600270 |
| 摘要 | Carbohydrate alterations on cell membranes are associated with various cancer processes, including tumorigenesis, malignant transformation, and tumor dissemination. However, variations in the distributions of cancer-associated carbohydrates are unclear at the molecular level. Herein, direct stochastic optical reconstruction microscopy is used to reveal that seven major types of carbohydrates tended to form obvious clusters on cancer cell membranes compared with normal cell membranes (both cultured and primary cells), and most types of carbohydrates present a similar distributed characteristic on various cancer cells (e.g., HeLa and Os-Rc-2 cells). Significantly, sialic acid is found to distribute in larger-sized clusters with a higher cluster coverage percentage on various cancer cells than normal cells. These findings on the aberrant distributions of cancer-associated carbohydrates can potentially serve as novel diagnostic and therapeutic targets, as well as making a contribution to clarify how abnormal glycosylations of membrane glycoconjugates participate in tumorigenesis and metastasis. |
| DOI | 10.1002/advs.201600270 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000390399000015 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/33797 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R China 2.Jilin Univ, Hosp 2, Changchun 130022, Jilin, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Junling,Liu, Tianzhou,Gao, Jing,et al. Variation in Carbohydrates between Cancer and Normal Cell Membranes Revealed by Super-Resolution Fluorescence Imaging[J]. ADVANCED SCIENCE,2016,3(12):1600270. |
| APA | Chen, Junling.,Liu, Tianzhou.,Gao, Jing.,Gao, Lan.,Zhou, Lulu.,...&Wang, Hongda.(2016).Variation in Carbohydrates between Cancer and Normal Cell Membranes Revealed by Super-Resolution Fluorescence Imaging.ADVANCED SCIENCE,3(12),1600270. |
| MLA | Chen, Junling,et al."Variation in Carbohydrates between Cancer and Normal Cell Membranes Revealed by Super-Resolution Fluorescence Imaging".ADVANCED SCIENCE 3.12(2016):1600270. |
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| advs212.pdf（3955KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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