New findings of cyclohexane-fused octahydroquinolizine alkaloids from Myrioneuron faberi
Cao, Ming-Ming1,2; Zhang, Jia-Hui2; Zhang, Yu2; Peng, Zong-Gen3,4; Jiang, Jian-Dong3,4; Hao, Xiao-Jiang2
2016-12-14
发表期刊TETRAHEDRON LETTERS
卷号57期号:50页码:5632-5635
摘要Cyclohexane-fused octahydroquinolizine (COHQ) alkaloids present an unwonted carbon framework among alkaloids isolated from genus Myrioneuron, which featured with bridge-ring and hemiacetal groups. Continued chemical investigation of Myrioneuron faberi led to the isolation of four COHQ related structures, beta-myrifabral C (1), alpha-myrifabral C (2), beta-myrifabral D (3), and alpha-myrifabral D (4). 1 and 2 were inseparable hemiacetal epimers (cluster A), as did 3 and 4 (cluster B). The structures of 1-4 were elucidated on basis of MS and NMR spectra. In vitro, cluster A showed moderate inhibition activity against hepatitis C virus (HCV) replication with therapeutic index (CC50/EC50) of 74.0. (C) 2016 Elsevier Ltd. All rights reserved.
关键词Myrioneuron Alkaloids Hemiacetal Epimers Lysine-based Origination
资助信息National Natural Science Foundation of China(21372228; 31500035)
DOI10.1016/j.tetlet.2016.11.001
收录类别SCI
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000389293100020
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/33783
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Nanjing Agr Univ, Coll Food Sci & Technol, Nanjing 210095, Jiangsu, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
3.Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China
4.Peking Union Med Coll, Beijing 100050, Peoples R China
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Cao, Ming-Ming,Zhang, Jia-Hui,Zhang, Yu,et al. New findings of cyclohexane-fused octahydroquinolizine alkaloids from Myrioneuron faberi[J]. TETRAHEDRON LETTERS,2016,57(50):5632-5635.
APA Cao, Ming-Ming,Zhang, Jia-Hui,Zhang, Yu,Peng, Zong-Gen,Jiang, Jian-Dong,&Hao, Xiao-Jiang.(2016).New findings of cyclohexane-fused octahydroquinolizine alkaloids from Myrioneuron faberi.TETRAHEDRON LETTERS,57(50),5632-5635.
MLA Cao, Ming-Ming,et al."New findings of cyclohexane-fused octahydroquinolizine alkaloids from Myrioneuron faberi".TETRAHEDRON LETTERS 57.50(2016):5632-5635.
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