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题名: New findings of cyclohexane-fused octahydroquinolizine alkaloids from Myrioneuron faberi
作者: Cao, Ming-Ming1, 2; Zhang, Jia-Hui2; Zhang, Yu2; Peng, Zong-Gen3, 4; Jiang, Jian-Dong3, 4; null(郝小江)2
刊名: TETRAHEDRON LETTERS
关键词: Myrioneuron alkaloids ; Hemiacetal epimers ; Lysine-based origination
英文摘要: Cyclohexane-fused octahydroquinolizine (COHQ) alkaloids present an unwonted carbon framework among alkaloids isolated from genus Myrioneuron, which featured with bridge-ring and hemiacetal groups. Continued chemical investigation of Myrioneuron faberi led to the isolation of four COHQ related structures, beta-myrifabral C (1), alpha-myrifabral C (2), beta-myrifabral D (3), and alpha-myrifabral D (4). 1 and 2 were inseparable hemiacetal epimers (cluster A), as did 3 and 4 (cluster B). The structures of 1-4 were elucidated on basis of MS and NMR spectra. In vitro, cluster A showed moderate inhibition activity against hepatitis C virus (HCV) replication with therapeutic index (CC50/EC50) of 74.0. (C) 2016 Elsevier Ltd. All rights reserved.
出版日期: 2016-12-14
卷号: 57, 期号:50, 页码:5632-5635
DOI标识: 10.1016/j.tetlet.2016.11.001
语种: 英语
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/33783
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Nanjing Agr Univ, Coll Food Sci & Technol, Nanjing 210095, Jiangsu, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
3.Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China
4.Peking Union Med Coll, Beijing 100050, Peoples R China

Recommended Citation:
Cao, Ming-Ming,Zhang, Jia-Hui,Zhang, Yu,et al. New findings of cyclohexane-fused octahydroquinolizine alkaloids from Myrioneuron faberi[J]. TETRAHEDRON LETTERS,2016,57(50):5632-5635.
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