| New findings of cyclohexane-fused octahydroquinolizine alkaloids from Myrioneuron faberi | |
Cao, Ming-Ming1,2; Zhang, Jia-Hui2 ; Zhang, Yu2; Peng, Zong-Gen3,4; Jiang, Jian-Dong3,4; Hao, Xiao-Jiang2
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| 2016-12-14 | |
| Source Publication | TETRAHEDRON LETTERS
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| Volume | 57Issue:50Pages:5632-5635 |
| Abstract | Cyclohexane-fused octahydroquinolizine (COHQ) alkaloids present an unwonted carbon framework among alkaloids isolated from genus Myrioneuron, which featured with bridge-ring and hemiacetal groups. Continued chemical investigation of Myrioneuron faberi led to the isolation of four COHQ related structures, beta-myrifabral C (1), alpha-myrifabral C (2), beta-myrifabral D (3), and alpha-myrifabral D (4). 1 and 2 were inseparable hemiacetal epimers (cluster A), as did 3 and 4 (cluster B). The structures of 1-4 were elucidated on basis of MS and NMR spectra. In vitro, cluster A showed moderate inhibition activity against hepatitis C virus (HCV) replication with therapeutic index (CC50/EC50) of 74.0. (C) 2016 Elsevier Ltd. All rights reserved. |
| Keyword | Myrioneuron Alkaloids Hemiacetal Epimers Lysine-based Origination |
| DOI | 10.1016/j.tetlet.2016.11.001 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000389293100020 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/33783 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Affiliation | 1.Nanjing Agr Univ, Coll Food Sci & Technol, Nanjing 210095, Jiangsu, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China 4.Peking Union Med Coll, Beijing 100050, Peoples R China |
| Recommended Citation GB/T 7714 | Cao, Ming-Ming,Zhang, Jia-Hui,Zhang, Yu,et al. New findings of cyclohexane-fused octahydroquinolizine alkaloids from Myrioneuron faberi[J]. TETRAHEDRON LETTERS,2016,57(50):5632-5635. |
| APA | Cao, Ming-Ming,Zhang, Jia-Hui,Zhang, Yu,Peng, Zong-Gen,Jiang, Jian-Dong,&Hao, Xiao-Jiang.(2016).New findings of cyclohexane-fused octahydroquinolizine alkaloids from Myrioneuron faberi.TETRAHEDRON LETTERS,57(50),5632-5635. |
| MLA | Cao, Ming-Ming,et al."New findings of cyclohexane-fused octahydroquinolizine alkaloids from Myrioneuron faberi".TETRAHEDRON LETTERS 57.50(2016):5632-5635. |
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