| Metal-Free Regioselective Hypervalent Iodine-Mediated C-2 and C-3 Difunctionalization of N-Substituted Indoles | |
Xu, Dongdong2,4; Sun, Wen-Wu1 ; Xie, Yanli2; Liu, Ji-Kai1; Liu, Bin2; Zhou, Yingbi2; Wu, Bin1,3
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| 2016-11-18 | |
| 发表期刊 | JOURNAL OF ORGANIC CHEMISTRY
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| 卷号 | 81期号:22页码:11081-11094 |
| 摘要 | Mild, metal-free, highly regioselective hypervalent-iodine mediated C-2 acetoxylation and C-3 oxidations of N-substituted indoles with (diacetoxyiodo)benzene [PhI-(OAc)(2)] have been reported. 'The reaction involves three cascade steps. The quantity of PhI(OAc)(2) employed in this reaction plays a key role in the outcome of three types of products (2a-4a). Furthermore, the mild and highly regioselective C-2 oxidation and C-3 dichlorination of N substituted indoles with PhICl2 have been developed. Extensive studies including in situ IR techniques and H2O18 - labeling experiment were performed to gain insight into the possible reaction mechanism. |
| DOI | 10.1021/acs.joc.6b02078 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000391248800045 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/33760 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Peoples R China 2.Shantou Univ, Cardiovasc Res Ctr, Coll Med, 22 Xin Ling Rd, Shantou 515041, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 4.First Peoples Hosp Yunnan Prov, PET CT Ctr, 157 Jinbi Rd, Kunming 650032, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Dongdong,Sun, Wen-Wu,Xie, Yanli,et al. Metal-Free Regioselective Hypervalent Iodine-Mediated C-2 and C-3 Difunctionalization of N-Substituted Indoles[J]. JOURNAL OF ORGANIC CHEMISTRY,2016,81(22):11081-11094. |
| APA | Xu, Dongdong.,Sun, Wen-Wu.,Xie, Yanli.,Liu, Ji-Kai.,Liu, Bin.,...&Wu, Bin.(2016).Metal-Free Regioselective Hypervalent Iodine-Mediated C-2 and C-3 Difunctionalization of N-Substituted Indoles.JOURNAL OF ORGANIC CHEMISTRY,81(22),11081-11094. |
| MLA | Xu, Dongdong,et al."Metal-Free Regioselective Hypervalent Iodine-Mediated C-2 and C-3 Difunctionalization of N-Substituted Indoles".JOURNAL OF ORGANIC CHEMISTRY 81.22(2016):11081-11094. |
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