Rearranged 6/6/5/6-Fused Triterpenoid Acids from the Stems of Kadsura coccinea
Hu, Zheng-Xi1,2; Hu, Kun2; Shi, Yi-Ming2; Wang, Wei-Guang2; Du, Xue2; Li, Yan2; Zhang, Yong-Hui1; Pu, Jian-Xin2; Sun, Han-Dong2
2016-10-01
Source PublicationJOURNAL OF NATURAL PRODUCTS
Volume79Issue:10Pages:2590-2598
AbstractFourteen new rearranged 6/6/5/6-fused triterpenoid acids, namely, kadcoccine acids A-N (1-14), were isolated from an EtOAc-soluble extract of the stems of Kadsura coccinea. Their structures were characterized mainly by analyzing 1D and 2D NMR and HRESIMS data and were shown to feature a rare 14(13 -> 12)-abeo-lanostane skeleton. Compounds 7 and 8 represented the first examples of a 5-substituted 2(5H)-furanone motif on the C-17 side chain of this skeleton. The absolute configurations of C-23 for compounds 1, 7, and 8 were determined by comparison of their experimental electronic circular dichroism spectra. All the isolates were screened for their in vitro cytotoxicity against six human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, SW-480, and HeLa), and compounds 2 and 8 exhibited weak inhibitory effects with IC50 values ranging from 3.11 to 7.77 mu M.
DOI10.1021/acs.jnatprod.6b00508
Indexed BySCI
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000386745300021
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Cited Times:12[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/33753
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Huazhong Univ Sci & Technol, Sch Pharm, Tongji Med Coll, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
Recommended Citation
GB/T 7714
Hu, Zheng-Xi,Hu, Kun,Shi, Yi-Ming,et al. Rearranged 6/6/5/6-Fused Triterpenoid Acids from the Stems of Kadsura coccinea[J]. JOURNAL OF NATURAL PRODUCTS,2016,79(10):2590-2598.
APA Hu, Zheng-Xi.,Hu, Kun.,Shi, Yi-Ming.,Wang, Wei-Guang.,Du, Xue.,...&Sun, Han-Dong.(2016).Rearranged 6/6/5/6-Fused Triterpenoid Acids from the Stems of Kadsura coccinea.JOURNAL OF NATURAL PRODUCTS,79(10),2590-2598.
MLA Hu, Zheng-Xi,et al."Rearranged 6/6/5/6-Fused Triterpenoid Acids from the Stems of Kadsura coccinea".JOURNAL OF NATURAL PRODUCTS 79.10(2016):2590-2598.
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