Rearranged 6/6/5/6-Fused Triterpenoid Acids from the Stems of Kadsura coccinea

doi:10.1021/acs.jnatprod.6b00508

	Rearranged 6/6/5/6-Fused Triterpenoid Acids from the Stems of Kadsura coccinea
	Hu, Zheng-Xi 1,2; Hu, Kun2 ; Shi, Yi-Ming2 ; Wang, Wei-Guang 2; Du, Xue 2; Li, Yan2 ; Zhang, Yong-Hui 1; Pu, Jian-Xin2 ; Sun, Han-Dong2
	2016-10-01
发表期刊	JOURNAL OF NATURAL PRODUCTS
卷号	79 期号:10 页码:2590-2598
摘要	Fourteen new rearranged 6/6/5/6-fused triterpenoid acids, namely, kadcoccine acids A-N (1-14), were isolated from an EtOAc-soluble extract of the stems of Kadsura coccinea. Their structures were characterized mainly by analyzing 1D and 2D NMR and HRESIMS data and were shown to feature a rare 14(13 -> 12)-abeo-lanostane skeleton. Compounds 7 and 8 represented the first examples of a 5-substituted 2(5H)-furanone motif on the C-17 side chain of this skeleton. The absolute configurations of C-23 for compounds 1, 7, and 8 were determined by comparison of their experimental electronic circular dichroism spectra. All the isolates were screened for their in vitro cytotoxicity against six human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, SW-480, and HeLa), and compounds 2 and 8 exhibited weak inhibitory effects with IC50 values ranging from 3.11 to 7.77 mu M.
DOI	10.1021/acs.jnatprod.6b00508
收录类别	SCI
语种	英语
WOS记录号	WOS:000386745300021
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/33753
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Huazhong Univ Sci & Technol, Sch Pharm, Tongji Med Coll, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
推荐引用方式 GB/T 7714	Hu, Zheng-Xi,Hu, Kun,Shi, Yi-Ming,et al. Rearranged 6/6/5/6-Fused Triterpenoid Acids from the Stems of Kadsura coccinea[J]. JOURNAL OF NATURAL PRODUCTS,2016,79(10):2590-2598.
APA	Hu, Zheng-Xi.,Hu, Kun.,Shi, Yi-Ming.,Wang, Wei-Guang.,Du, Xue.,...&Sun, Han-Dong.(2016).Rearranged 6/6/5/6-Fused Triterpenoid Acids from the Stems of Kadsura coccinea.JOURNAL OF NATURAL PRODUCTS,79(10),2590-2598.
MLA	Hu, Zheng-Xi,et al."Rearranged 6/6/5/6-Fused Triterpenoid Acids from the Stems of Kadsura coccinea".JOURNAL OF NATURAL PRODUCTS 79.10(2016):2590-2598.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
acs.jnatprod.6b00508（979KB）	期刊论文	作者接受稿	开放获取	CC BY-NC-SA	浏览下载