| Cloning and characterization of MHC-DQA1 and MHC-DQA2 molecules from yak (Bos grunniens) | |
| Ge, Fei1; Memon, Sameeullah1; Xi, Dongmei1; Li, Shijun1; Liu, Xiangying1; Li, Guozhi1; Wang, Liping1; Leng, Jing1; Khan, Sehroon2,3; Deng, Weidong1 | |
| 2016 | |
| Source Publication | ARCHIVES ANIMAL BREEDING
 |
| Volume | 59Issue:3Pages:395-400 |
| Abstract | The major histocompatibility complex (MHC) plays a crucial role in the processing and presentation of antigens and in discrimination between self and non-self. The aim of this investigation was to scrutinize the structural diversity and possible duplication of the MHC-DQA genes in yak (Bos grunniens). Two cDNA sequences were amplified and designated as Bogr-DQA1 (DQA * 0101) and Bogr-DQA2 (DQA * 2001) with GenBank accession numbers JQ864314 and JQ864315, respectively. The nucleotide and amino acid sequence alignment between Bogr-DQA1 and Bogr-DQA2 molecules showed that these two identified MHC-DQA gene sequences had more similarity to alleles of specific DQA1 and DQA2 genes from other Ruminantia species than to each other. The result from phylogenic investigation also revealed that there was a larger genetic distance between these two genes than between homologous genes from different species. The presence of different bovine DQA putative motifs and the large genetic distance between Bogr-DQA1 and Bogr-DQA2 suggest that these sequences are non-allelic. Further, these results indicate that DQA gene duplication occurs in ruminants. This study will be helpful in knowing MHC diversity in common ruminants and will deepen our understanding of the variation of immunological functions, evolutionary constraints, and selective forces that affect MHC variation within and between species. |
| DOI | 10.5194/aab-59-395-2016 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000383420000010 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/33632 |
| Collection | 资源植物与生物技术所级重点实验室 |
| Affiliation | 1.Yunnan Agr Univ, Fac Anim Sci & Technol, Yunnan Prov Key Lab Anim Nutr & Feed, Kunming 650201, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Ctr Mt Ecosyst Studies, Kunming 650201, Peoples R China 3.World Agroforestry Ctr, Kunming 650201, Peoples R China |
| Recommended Citation GB/T 7714 | Ge, Fei,Memon, Sameeullah,Xi, Dongmei,et al. Cloning and characterization of MHC-DQA1 and MHC-DQA2 molecules from yak (Bos grunniens)[J]. ARCHIVES ANIMAL BREEDING,2016,59(3):395-400. |
| APA | Ge, Fei.,Memon, Sameeullah.,Xi, Dongmei.,Li, Shijun.,Liu, Xiangying.,...&Deng, Weidong.(2016).Cloning and characterization of MHC-DQA1 and MHC-DQA2 molecules from yak (Bos grunniens).ARCHIVES ANIMAL BREEDING,59(3),395-400. |
| MLA | Ge, Fei,et al."Cloning and characterization of MHC-DQA1 and MHC-DQA2 molecules from yak (Bos grunniens)".ARCHIVES ANIMAL BREEDING 59.3(2016):395-400. |
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| aab-59-395-2016.pdf（1387KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Download | |
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