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Cloning and characterization of MHC-DQA1 and MHC-DQA2 molecules from yak (Bos grunniens)
Ge, Fei1; Memon, Sameeullah1; Xi, Dongmei1; Li, Shijun1; Liu, Xiangying1; Li, Guozhi1; Wang, Liping1; Leng, Jing1; Khan, Sehroon2,3; Deng, Weidong1
2016
Source PublicationARCHIVES ANIMAL BREEDING
Volume59Issue:3Pages:395-400
AbstractThe major histocompatibility complex (MHC) plays a crucial role in the processing and presentation of antigens and in discrimination between self and non-self. The aim of this investigation was to scrutinize the structural diversity and possible duplication of the MHC-DQA genes in yak (Bos grunniens). Two cDNA sequences were amplified and designated as Bogr-DQA1 (DQA * 0101) and Bogr-DQA2 (DQA * 2001) with GenBank accession numbers JQ864314 and JQ864315, respectively. The nucleotide and amino acid sequence alignment between Bogr-DQA1 and Bogr-DQA2 molecules showed that these two identified MHC-DQA gene sequences had more similarity to alleles of specific DQA1 and DQA2 genes from other Ruminantia species than to each other. The result from phylogenic investigation also revealed that there was a larger genetic distance between these two genes than between homologous genes from different species. The presence of different bovine DQA putative motifs and the large genetic distance between Bogr-DQA1 and Bogr-DQA2 suggest that these sequences are non-allelic. Further, these results indicate that DQA gene duplication occurs in ruminants. This study will be helpful in knowing MHC diversity in common ruminants and will deepen our understanding of the variation of immunological functions, evolutionary constraints, and selective forces that affect MHC variation within and between species.
DOI10.5194/aab-59-395-2016
Indexed BySCI
Language英语
WOS IDWOS:000383420000010
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/33632
Collection资源植物与生物技术所级重点实验室
Affiliation1.Yunnan Agr Univ, Fac Anim Sci & Technol, Yunnan Prov Key Lab Anim Nutr & Feed, Kunming 650201, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Ctr Mt Ecosyst Studies, Kunming 650201, Peoples R China
3.World Agroforestry Ctr, Kunming 650201, Peoples R China
Recommended Citation
GB/T 7714
Ge, Fei,Memon, Sameeullah,Xi, Dongmei,et al. Cloning and characterization of MHC-DQA1 and MHC-DQA2 molecules from yak (Bos grunniens)[J]. ARCHIVES ANIMAL BREEDING,2016,59(3):395-400.
APA Ge, Fei.,Memon, Sameeullah.,Xi, Dongmei.,Li, Shijun.,Liu, Xiangying.,...&Deng, Weidong.(2016).Cloning and characterization of MHC-DQA1 and MHC-DQA2 molecules from yak (Bos grunniens).ARCHIVES ANIMAL BREEDING,59(3),395-400.
MLA Ge, Fei,et al."Cloning and characterization of MHC-DQA1 and MHC-DQA2 molecules from yak (Bos grunniens)".ARCHIVES ANIMAL BREEDING 59.3(2016):395-400.
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