Six new physalins from Physalis alkekengi var. franchetii and their cytotoxicity and antibacterial activity
Yang, Ye-Kun1,2; Xie, Si-da1; Xu, Wan-xuan1; Nian, Yin1; Liu, Xiao-Ling1; Peng, Xing-Rong1; Ding, Zhong-Tao2; Qiu, Ming-Hua1
2016-07-01
Source PublicationFITOTERAPIA
Volume112Pages:144-152
AbstractSix new physalin steroids, 7 beta-methoxylisophysalin B (1), 7 beta-methoxylphysalin C (2), physalin V (3), physalin VI (4), physalin VII (5), isophysalin I (6), together with 20 known physalins (7-26) were isolated from calyces of Physalis alkekengi var. franchetii. Structures of the new compounds were revealed through 10 and 2D NMR and mass spectroscopic methods. Compounds 1-26 were evaluated for cytotoxicity against human HL-60, SMMC-7721, A-549, MCF-7 and SW-480, and the results indicated that compounds 8,11, and 14 displayed-potent cytotoxicities (IC50 < 5 mu M) in vitro. Further antibacterial assay indicated that compounds 8,14, and 19 showed high antibacterial activities against Bacillus subtilis and Escherichia coli. (C) 2016 Elsevier B.V. All rights reserved.
KeywordPhysalis Alkekengi Var. Franchetii Steroid Physalin Neophysalin
DOI10.1016/j.fitote.2016.05.010
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000380865400018
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/33598
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Yunnan Univ, Sch Chem Sci & Technol, Kunming 650091, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Yang, Ye-Kun,Xie, Si-da,Xu, Wan-xuan,et al. Six new physalins from Physalis alkekengi var. franchetii and their cytotoxicity and antibacterial activity[J]. FITOTERAPIA,2016,112:144-152.
APA Yang, Ye-Kun.,Xie, Si-da.,Xu, Wan-xuan.,Nian, Yin.,Liu, Xiao-Ling.,...&Qiu, Ming-Hua.(2016).Six new physalins from Physalis alkekengi var. franchetii and their cytotoxicity and antibacterial activity.FITOTERAPIA,112,144-152.
MLA Yang, Ye-Kun,et al."Six new physalins from Physalis alkekengi var. franchetii and their cytotoxicity and antibacterial activity".FITOTERAPIA 112(2016):144-152.
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