| Six new physalins from Physalis alkekengi var. franchetii and their cytotoxicity and antibacterial activity | |
Yang, Ye-Kun1,2; Xie, Si-da1; Xu, Wan-xuan1; Nian, Yin1 ; Liu, Xiao-Ling1; Peng, Xing-Rong1; Ding, Zhong-Tao2; Qiu, Ming-Hua1
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| 2016-07-01 | |
| 发表期刊 | FITOTERAPIA
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| 卷号 | 112页码:144-152 |
| 摘要 | Six new physalin steroids, 7 beta-methoxylisophysalin B (1), 7 beta-methoxylphysalin C (2), physalin V (3), physalin VI (4), physalin VII (5), isophysalin I (6), together with 20 known physalins (7-26) were isolated from calyces of Physalis alkekengi var. franchetii. Structures of the new compounds were revealed through 10 and 2D NMR and mass spectroscopic methods. Compounds 1-26 were evaluated for cytotoxicity against human HL-60, SMMC-7721, A-549, MCF-7 and SW-480, and the results indicated that compounds 8,11, and 14 displayed-potent cytotoxicities (IC50 < 5 mu M) in vitro. Further antibacterial assay indicated that compounds 8,14, and 19 showed high antibacterial activities against Bacillus subtilis and Escherichia coli. (C) 2016 Elsevier B.V. All rights reserved. |
| 关键词 | Physalis Alkekengi Var. Franchetii Steroid Physalin Neophysalin |
| DOI | 10.1016/j.fitote.2016.05.010 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000380865400018 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/33598 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Yunnan Univ, Sch Chem Sci & Technol, Kunming 650091, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Ye-Kun,Xie, Si-da,Xu, Wan-xuan,et al. Six new physalins from Physalis alkekengi var. franchetii and their cytotoxicity and antibacterial activity[J]. FITOTERAPIA,2016,112:144-152. |
| APA | Yang, Ye-Kun.,Xie, Si-da.,Xu, Wan-xuan.,Nian, Yin.,Liu, Xiao-Ling.,...&Qiu, Ming-Hua.(2016).Six new physalins from Physalis alkekengi var. franchetii and their cytotoxicity and antibacterial activity.FITOTERAPIA,112,144-152. |
| MLA | Yang, Ye-Kun,et al."Six new physalins from Physalis alkekengi var. franchetii and their cytotoxicity and antibacterial activity".FITOTERAPIA 112(2016):144-152. |
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