Phleghenrines A-D and Neophleghenrine A, Bioactive and Structurally Rigid Lycopodium Alkaloids from Phlegmariurus henryi

doi:10.1021/acs.orglett.6b02065

	Phleghenrines A-D and Neophleghenrine A, Bioactive and Structurally Rigid Lycopodium Alkaloids from Phlegmariurus henryi
	Dong, Liao-Bin 1,2; Wu, Xing-De 1; Shi, Xin 1; Zhang, Zhi-Jun 1; Yang, Jing1 ; Zhao, Qin-Shi1
	2016-09-16
发表期刊	ORGANIC LETTERS
卷号	18 期号:18 页码:4498-4501
摘要	Five new Lycopodium alkaloids, phleghenrines A-D (1-4) and neophleghenrine A (5), were isolated from Phlegmariurus henryi (Baker) Ching. The structures and absolute configurations of 1-5 were determined using extensive spectroscopic data coupled with computational calculations and revealed 1-4 possess a bicyclo [3.2.2]-nonane core, whereas 5 possesses an unprecedented 9-azaprotoadamantane core. Compounds 1 and 4 showed potent acetyl-cholinesterase (AChE) inhibitory activities, and 4 is a good lead natural product for the treatment of Alzheimer's disease.
DOI	10.1021/acs.orglett.6b02065
收录类别	SCI
语种	英语
WOS记录号	WOS:000383640600014
引用统计	被引频次：32[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/33585
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Scripps Res Inst, Dept Chem, Jupiter, FL 33458 USA
推荐引用方式 GB/T 7714	Dong, Liao-Bin,Wu, Xing-De,Shi, Xin,et al. Phleghenrines A-D and Neophleghenrine A, Bioactive and Structurally Rigid Lycopodium Alkaloids from Phlegmariurus henryi[J]. ORGANIC LETTERS,2016,18(18):4498-4501.
APA	Dong, Liao-Bin,Wu, Xing-De,Shi, Xin,Zhang, Zhi-Jun,Yang, Jing,&Zhao, Qin-Shi.(2016).Phleghenrines A-D and Neophleghenrine A, Bioactive and Structurally Rigid Lycopodium Alkaloids from Phlegmariurus henryi.ORGANIC LETTERS,18(18),4498-4501.
MLA	Dong, Liao-Bin,et al."Phleghenrines A-D and Neophleghenrine A, Bioactive and Structurally Rigid Lycopodium Alkaloids from Phlegmariurus henryi".ORGANIC LETTERS 18.18(2016):4498-4501.

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