| Phleghenrines A-D and Neophleghenrine A, Bioactive and Structurally Rigid Lycopodium Alkaloids from Phlegmariurus henryi | |
Dong, Liao-Bin1,2; Wu, Xing-De1; Shi, Xin1; Zhang, Zhi-Jun1; Yang, Jing1 ; Zhao, Qin-Shi1
| |
| 2016-09-16 | |
| 发表期刊 | ORGANIC LETTERS
 |
| 卷号 | 18期号:18页码:4498-4501 |
| 摘要 | Five new Lycopodium alkaloids, phleghenrines A-D (1-4) and neophleghenrine A (5), were isolated from Phlegmariurus henryi (Baker) Ching. The structures and absolute configurations of 1-5 were determined using extensive spectroscopic data coupled with computational calculations and revealed 1-4 possess a bicyclo [3.2.2]-nonane core, whereas 5 possesses an unprecedented 9-azaprotoadamantane core. Compounds 1 and 4 showed potent acetyl-cholinesterase (AChE) inhibitory activities, and 4 is a good lead natural product for the treatment of Alzheimer's disease. |
| DOI | 10.1021/acs.orglett.6b02065 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000383640600014 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/33585 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Scripps Res Inst, Dept Chem, Jupiter, FL 33458 USA |
| 推荐引用方式 GB/T 7714 | Dong, Liao-Bin,Wu, Xing-De,Shi, Xin,et al. Phleghenrines A-D and Neophleghenrine A, Bioactive and Structurally Rigid Lycopodium Alkaloids from Phlegmariurus henryi[J]. ORGANIC LETTERS,2016,18(18):4498-4501. |
| APA | Dong, Liao-Bin,Wu, Xing-De,Shi, Xin,Zhang, Zhi-Jun,Yang, Jing,&Zhao, Qin-Shi.(2016).Phleghenrines A-D and Neophleghenrine A, Bioactive and Structurally Rigid Lycopodium Alkaloids from Phlegmariurus henryi.ORGANIC LETTERS,18(18),4498-4501. |
| MLA | Dong, Liao-Bin,et al."Phleghenrines A-D and Neophleghenrine A, Bioactive and Structurally Rigid Lycopodium Alkaloids from Phlegmariurus henryi".ORGANIC LETTERS 18.18(2016):4498-4501. |
| 条目包含的文件 | 下载所有文件 | |||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| acs.orglett.6b02065.（439KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论