Anticomplement activity of cycloartane glycosides from the rhizome of Cimicifuga foetida
Qiu, Minghua; Kim, Jung-Hee; Lee, Hyeong-Kyu; Min, Byung-Sun
2006-11-01
发表期刊PHYTOTHERAPY RESEARCH
ISSN0951-418X
卷号20期号:11页码:945-948
摘要A tetranor-cycloartane glycoside and two 9,19-cycloartane glycosides were isolated from the EtOAc-soluble fraction of the rhizome of Cimicifuga foetida. The structures of the compounds were determined to be cimilactone A (1), 25-O-acetylcimigenol 3-O-beta-D-xylopyranoside (2) and cimigenol 3-O-alpha-L-arabinopyranoside (3), respectively, using spectroscopic analysis. The three compounds were examined for their anticomplement activity against the classical pathway of the complement system. Compound 1 showed significant anticomplement activity with an IC50 value of 28.6 mu m, whereas compounds 2 and 3 were inactive. Copyright (c) 2006 John Wiley & Sons, Ltd.
关键词Cimicifuga Foetida Cycloartane-type Triterpenoid Anticomplement Activity Cimilactone a
收录类别SCI
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/2971
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Catholic Univ Daegu, Coll Pharm, Gyeongbuk 712702, South Korea
2.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
3.Korea Res Inst Biosci & Biotechnol, Taejon 305333, South Korea
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Qiu, Minghua,Kim, Jung-Hee,Lee, Hyeong-Kyu,et al. Anticomplement activity of cycloartane glycosides from the rhizome of Cimicifuga foetida[J]. PHYTOTHERAPY RESEARCH,2006,20(11):945-948.
APA Qiu, Minghua,Kim, Jung-Hee,Lee, Hyeong-Kyu,&Min, Byung-Sun.(2006).Anticomplement activity of cycloartane glycosides from the rhizome of Cimicifuga foetida.PHYTOTHERAPY RESEARCH,20(11),945-948.
MLA Qiu, Minghua,et al."Anticomplement activity of cycloartane glycosides from the rhizome of Cimicifuga foetida".PHYTOTHERAPY RESEARCH 20.11(2006):945-948.
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