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题名: Anticomplement activity of cycloartane glycosides from the rhizome of Cimicifuga foetida
作者: null(邱明华); Kim, Jung-Hee; Lee, Hyeong-Kyu; Min, Byung-Sun
刊名: PHYTOTHERAPY RESEARCH
关键词: Cimicifuga foetida ; cycloartane-type triterpenoid ; anticomplement activity ; cimilactone A
英文摘要: A tetranor-cycloartane glycoside and two 9,19-cycloartane glycosides were isolated from the EtOAc-soluble fraction of the rhizome of Cimicifuga foetida. The structures of the compounds were determined to be cimilactone A (1), 25-O-acetylcimigenol 3-O-beta-D-xylopyranoside (2) and cimigenol 3-O-alpha-L-arabinopyranoside (3), respectively, using spectroscopic analysis. The three compounds were examined for their anticomplement activity against the classical pathway of the complement system. Compound 1 showed significant anticomplement activity with an IC50 value of 28.6 mu m, whereas compounds 2 and 3 were inactive. Copyright (c) 2006 John Wiley & Sons, Ltd.
出版日期: 2006-11-01
卷号: 20, 期号:11, 页码:945-948
DOI标识: 10.1002/ptr.1982
语种: 英语
收录类别: SCI
学科分类: Chemistry, Medicinal; Pharmacology & Pharmacy
ISSN号: 0951-418X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/2971
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Catholic Univ Daegu, Coll Pharm, Gyeongbuk 712702, South Korea
2.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
3.Korea Res Inst Biosci & Biotechnol, Taejon 305333, South Korea

Recommended Citation:
Qiu, MH; Kim, JH; Lee, HK; Min, BS.Anticomplement activity of cycloartane glycosides from the rhizome of Cimicifuga foetida,PHYTOTHERAPY RESEARCH,2006,20(11):945-948
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