Grifolin, a potential antitumor natural product from the mushroom Albatrellus confluens, induces cell-cycle arrest in G1 phase via the ERK1/2 pathway
Ye, Mao1,3; Luo, Xiangjian1; Li, Lili1; Shi, Ying1; Tan, Ming1; Weng, Xinxian1; Li, Wei1; Liu, Jikai2; Cao, Ya1
2007-12-18
发表期刊CANCER LETTERS
ISSN0304-3835
卷号258期号:2页码:199-207
摘要Grifolin, a natural product isolated from the mushroom Albatrellus confluens, has been shown to inhibit the growth of some cancer cell lines and induce significant apoptosis. However, the molecular targets and the signaling mechanism underlying the anticancer effect of this compound are not completely understood. Here, we undertook a gene expression profiling study to identify novel targets of grifolin. We found that the effect of grifolin on the human nasopharyngeal carcinoma cell line CNE1 occurs primarily via the ERK1/2 pathway. At high doses, both the ERK1/2 and the ERK5 pathways may be involved in the inhibition. Because inhibition of the ERK1/2 or the ERK5 pathway has been associated with cell-cycle arrest and growth inhibition, we evaluated the cell cycle distribution after grifolin treatment. We found that grifolin significantly caused cell-cycle arrest in G1 phase. To investigate the underlying mechanisms, G1-related proteins were assayed by Western blotting. Following grifolin treatment, a concomitant inhibition of cyclin D1, cyclin E, CDK4 expression, and subsequent reduction in pRB phosphorylation occurred. Meanwhile, grifolin treatment also resulted in a significant upregulation of CKI (p19(INK4D)). These results suggest that the inhibition of the ERK1/2 or the ERK5 pathway is responsible for at least part of the induction of cell-cycle arrest in G1 phase by grifolin. These results are significant in that they provide a mechanistic framework for further exploring the use of grifolin as a novel antitumor agent. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
关键词Grifolin Cell Cycle Erk1/2 Erk5
学科领域Oncology
DOI10.1016/j.canlet.2007.09.001
收录类别SCI
语种英语
WOS研究方向Oncology
WOS类目Oncology
WOS记录号WOS:000251852600006
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被引频次:37[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/2951
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.S Cent Univ, Xiangya Sch Med, Canc Res Inst, Changsha 410078, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Dept Phytochem, Kunming 650204, Peoples R China
3.Wenzhou Med Coll, Sch Ophthalmol & Optometry, Zhejiang 325027, Peoples R China
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Ye, Mao,Luo, Xiangjian,Li, Lili,et al. Grifolin, a potential antitumor natural product from the mushroom Albatrellus confluens, induces cell-cycle arrest in G1 phase via the ERK1/2 pathway[J]. CANCER LETTERS,2007,258(2):199-207.
APA Ye, Mao.,Luo, Xiangjian.,Li, Lili.,Shi, Ying.,Tan, Ming.,...&Cao, Ya.(2007).Grifolin, a potential antitumor natural product from the mushroom Albatrellus confluens, induces cell-cycle arrest in G1 phase via the ERK1/2 pathway.CANCER LETTERS,258(2),199-207.
MLA Ye, Mao,et al."Grifolin, a potential antitumor natural product from the mushroom Albatrellus confluens, induces cell-cycle arrest in G1 phase via the ERK1/2 pathway".CANCER LETTERS 258.2(2007):199-207.
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