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题名: Grifolin, a potential antitumor natural product from the mushroom Albatrellus confluens, induces cell-cycle arrest in G1 phase via the ERK1/2 pathway
作者: Ye, Mao1, 3; Luo, Xiangjian1; Li, Lili1; Shi, Ying1; Tan, Ming1; Weng, Xinxian1; Li, Wei1; Liu, Jikai2; Cao, Ya1
刊名: CANCER LETTERS
关键词: grifolin ; cell cycle ; ERK1/2 ; ERK5
英文摘要: Grifolin, a natural product isolated from the mushroom Albatrellus confluens, has been shown to inhibit the growth of some cancer cell lines and induce significant apoptosis. However, the molecular targets and the signaling mechanism underlying the anticancer effect of this compound are not completely understood. Here, we undertook a gene expression profiling study to identify novel targets of grifolin. We found that the effect of grifolin on the human nasopharyngeal carcinoma cell line CNE1 occurs primarily via the ERK1/2 pathway. At high doses, both the ERK1/2 and the ERK5 pathways may be involved in the inhibition. Because inhibition of the ERK1/2 or the ERK5 pathway has been associated with cell-cycle arrest and growth inhibition, we evaluated the cell cycle distribution after grifolin treatment. We found that grifolin significantly caused cell-cycle arrest in G1 phase. To investigate the underlying mechanisms, G1-related proteins were assayed by Western blotting. Following grifolin treatment, a concomitant inhibition of cyclin D1, cyclin E, CDK4 expression, and subsequent reduction in pRB phosphorylation occurred. Meanwhile, grifolin treatment also resulted in a significant upregulation of CKI (p19(INK4D)). These results suggest that the inhibition of the ERK1/2 or the ERK5 pathway is responsible for at least part of the induction of cell-cycle arrest in G1 phase by grifolin. These results are significant in that they provide a mechanistic framework for further exploring the use of grifolin as a novel antitumor agent. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
出版日期: 2007-12-18
卷号: 258, 期号:2, 页码:199-207
DOI标识: 10.1016/j.canlet.2007.09.001
语种: 英语
ISSN号: 0304-3835
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/2951
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.S Cent Univ, Xiangya Sch Med, Canc Res Inst, Changsha 410078, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Dept Phytochem, Kunming 650204, Peoples R China
3.Wenzhou Med Coll, Sch Ophthalmol & Optometry, Zhejiang 325027, Peoples R China

Recommended Citation:
Ye, M; Luo, XJ; Li, LL; Shi, Y; Tan, M; Weng, XX; Li, W; Liu, JK; Cao, Y.Grifolin, a potential antitumor natural product from the mushroom Albatrellus confluens, induces cell-cycle arrest in G1 phase via the ERK1/2 pathway,CANCER LETTERS,2007,258(2):199-207
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