Abiesanordines A-N: fourteen new norditerpenes from Abies georgei

doi:10.1016/j.tet.2008.02.069

	Abiesanordines A-N: fourteen new norditerpenes from Abies georgei
	Yang, Xian-Wen 1; Li, Su-Mei 2; Feng, Lin 3; Shen, Yun-Heng 1; Tian, Jun-Mian 1; Liu, Xiao-Hua 1; Zeng, Hua-Wu 1; Zhang, Chuan 1; Zhang, Wei-Dong 1,4
通讯作者	zc100@citiz.net ; wdzhangy@hotmail.com
	2008-05-05
发表期刊	TETRAHEDRON
ISSN	0040-4020
卷号	64 期号:19 页码:4354-4362
摘要	Fourteen new norditerpenoids (abiesanordines A-N, 1-14), including a novel podocarpene bearing a rare enolic structure (abiesanordine A, 1). were isolated from Abies georgei together with eight known ones. Their structures were determined mainly by detailed analysis of 1D and 2D NMR spectroscopic data including HSQC, DQF COSY, HMBC, and NOESY. All the isolates were tested for inhibitory activities against LPS-induced NO production in RAW264.7 macrophages, abiesanordine 1 (9) showed the strongest activity with the IC50 value of 17.0 mu g/mL. Furthermore, it exhibited no cytotoxicity against RAW264.7 macrophages under the concentration of 50 mu g/mL. (c) 2008 Elsevier Ltd. All rights reserved.
关键词	Abies Georgei Pinaceae Norditerpenoids Podocarpenes Abiesanordines A-n Nitric Oxide (No) Raw264.7 Macrophages
学科领域	Chemistry, Organic
DOI	10.1016/j.tet.2008.02.069
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000255585600024
引用统计	被引频次：57[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/2935
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Second Mil Med Univ, Sch Pharm, Dept Nat Prod Chem, Shanghai 200433, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Dept Ethnobot, Kunming 650204, Peoples R China 3.Jiangxi Univ Tradit Chinese Med, Dept Pharm, Nanchang 330004, Peoples R China 4.Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China
推荐引用方式 GB/T 7714	Yang, Xian-Wen,Li, Su-Mei,Feng, Lin,et al. Abiesanordines A-N: fourteen new norditerpenes from Abies georgei[J]. TETRAHEDRON,2008,64(19):4354-4362.
APA	Yang, Xian-Wen.,Li, Su-Mei.,Feng, Lin.,Shen, Yun-Heng.,Tian, Jun-Mian.,...&Zhang, Wei-Dong.(2008).Abiesanordines A-N: fourteen new norditerpenes from Abies georgei.TETRAHEDRON,64(19),4354-4362.
MLA	Yang, Xian-Wen,et al."Abiesanordines A-N: fourteen new norditerpenes from Abies georgei".TETRAHEDRON 64.19(2008):4354-4362.

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