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题名: Abiesanordines A-N: fourteen new norditerpenes from Abies georgei
作者: Yang, Xian-Wen1; Li, Su-Mei2; Feng, Lin3; Shen, Yun-Heng1; Tian, Jun-Mian1; Liu, Xiao-Hua1; Zeng, Hua-Wu1; Zhang, Chuan1; Zhang, Wei-Dong1, 4
刊名: TETRAHEDRON
关键词: Abies georgei ; pinaceae ; norditerpenoids ; podocarpenes ; abiesanordines A-N ; nitric oxide (NO) ; RAW264.7 macrophages
英文摘要: Fourteen new norditerpenoids (abiesanordines A-N, 1-14), including a novel podocarpene bearing a rare enolic structure (abiesanordine A, 1). were isolated from Abies georgei together with eight known ones. Their structures were determined mainly by detailed analysis of 1D and 2D NMR spectroscopic data including HSQC, DQF COSY, HMBC, and NOESY. All the isolates were tested for inhibitory activities against LPS-induced NO production in RAW264.7 macrophages, abiesanordine 1 (9) showed the strongest activity with the IC50 value of 17.0 mu g/mL. Furthermore, it exhibited no cytotoxicity against RAW264.7 macrophages under the concentration of 50 mu g/mL. (c) 2008 Elsevier Ltd. All rights reserved.
出版日期: 2008-05-05
卷号: 64, 期号:19, 页码:4354-4362
语种: 英语
收录类别: SCI ; IC
学科分类: Chemistry, Organic
ISSN号: 0040-4020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/2935
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Second Mil Med Univ, Sch Pharm, Dept Nat Prod Chem, Shanghai 200433, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Dept Ethnobot, Kunming 650204, Peoples R China
3.Jiangxi Univ Tradit Chinese Med, Dept Pharm, Nanchang 330004, Peoples R China
4.Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China

Recommended Citation:
Yang, XW; Li, SM; Feng, L; Shen, YH; Tian, JM; Liu, XH; Zeng, HW; Zhang, C; Zhang, WD.Abiesanordines A-N: fourteen new norditerpenes from Abies georgei,TETRAHEDRON,2008,64(19):4354-4362
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