Abiesanordines A-N: fourteen new norditerpenes from Abies georgei
Yang, Xian-Wen1; Li, Su-Mei2; Feng, Lin3; Shen, Yun-Heng1; Tian, Jun-Mian1; Liu, Xiao-Hua1; Zeng, Hua-Wu1; Zhang, Chuan1; Zhang, Wei-Dong1,4
2008-05-05
发表期刊TETRAHEDRON
ISSN0040-4020
卷号64期号:19页码:4354-4362
摘要Fourteen new norditerpenoids (abiesanordines A-N, 1-14), including a novel podocarpene bearing a rare enolic structure (abiesanordine A, 1). were isolated from Abies georgei together with eight known ones. Their structures were determined mainly by detailed analysis of 1D and 2D NMR spectroscopic data including HSQC, DQF COSY, HMBC, and NOESY. All the isolates were tested for inhibitory activities against LPS-induced NO production in RAW264.7 macrophages, abiesanordine 1 (9) showed the strongest activity with the IC50 value of 17.0 mu g/mL. Furthermore, it exhibited no cytotoxicity against RAW264.7 macrophages under the concentration of 50 mu g/mL. (c) 2008 Elsevier Ltd. All rights reserved.
关键词Abies Georgei Pinaceae Norditerpenoids Podocarpenes Abiesanordines A-n Nitric Oxide (No) Raw264.7 Macrophages
学科领域Chemistry, Organic
DOI10.1016/j.tet.2008.02.069
收录类别SCI ; IC
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000255585600024
引用统计
被引频次:43[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/2935
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Second Mil Med Univ, Sch Pharm, Dept Nat Prod Chem, Shanghai 200433, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Dept Ethnobot, Kunming 650204, Peoples R China
3.Jiangxi Univ Tradit Chinese Med, Dept Pharm, Nanchang 330004, Peoples R China
4.Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China
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Yang, Xian-Wen,Li, Su-Mei,Feng, Lin,et al. Abiesanordines A-N: fourteen new norditerpenes from Abies georgei[J]. TETRAHEDRON,2008,64(19):4354-4362.
APA Yang, Xian-Wen.,Li, Su-Mei.,Feng, Lin.,Shen, Yun-Heng.,Tian, Jun-Mian.,...&Zhang, Wei-Dong.(2008).Abiesanordines A-N: fourteen new norditerpenes from Abies georgei.TETRAHEDRON,64(19),4354-4362.
MLA Yang, Xian-Wen,et al."Abiesanordines A-N: fourteen new norditerpenes from Abies georgei".TETRAHEDRON 64.19(2008):4354-4362.
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