| Abiesanol A, a novel biflavanol with unique six connective hexacyclic rings isolated from Abies georgei | |
| Yang, Xian-Wen1; Li, Su-Mei2; Feng, Lin3; Shen, Yun-Heng1; Tian, Jun-Mian1; Zeng, Hua-Wu1; Liu, Xiao-Hua1; Shan, Lei1; Su, Juan1; Zhang, Chuan1; Zhang, Wei-Dong1,4 | |
| 通讯作者 | zc100@citiz.net ; wdzhangy@hotmail.com |
| 2008-05-05 | |
| 发表期刊 | TETRAHEDRON LETTERS
 |
| ISSN | 0040-4039 |
| 卷号 | 49期号:19页码:3042-3044 |
| 摘要 | A novel biffavanol with unique six connective hexacyclic rings, abiesanol A (1), was isolated from the aerial parts of Abies georgei together with four known flavanols. The structure of new compound was elucidated mainly by the analysis of ID and 2D NMR spectroscopic data. In addition, single-crystal X-ray diffraction analysis was adopted to confirm the structure of abiesanol A (1). In biological assay for inhibitory activities against LPS-induced nitric oxide (NO) production in RAW264.7 macrophages, abiesanol A (1) showed potent effects at 50 mu g/mL with the inhibition rate of 43.0%. Under the same concentration, abiesanol A (1) did not show any cytotoxicity against RAW264.7 macrophages. (C) 2008 Elsevier Ltd. All rights reserved. |
| 关键词 | Abies Georgei Pinaceae Biflavanol Abiesanol a Nitric Oxide (No) Raw264.7 Macrophages |
| 学科领域 | Chemistry, Organic |
| DOI | 10.1016/j.tetlet.2008.03.065 |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000255774700002 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/2927 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Second Mil Med Univ, Sch Pharm, Dept Nat Prod Chem, Shanghai 200433, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Dept Ethnobot, Kunming 650204, Peoples R China 3.Jiangxi Univ Tradit Chinese Med, Dept Pharm, Nanchang 330004, Peoples R China 4.Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Xian-Wen,Li, Su-Mei,Feng, Lin,et al. Abiesanol A, a novel biflavanol with unique six connective hexacyclic rings isolated from Abies georgei[J]. TETRAHEDRON LETTERS,2008,49(19):3042-3044. |
| APA | Yang, Xian-Wen.,Li, Su-Mei.,Feng, Lin.,Shen, Yun-Heng.,Tian, Jun-Mian.,...&Zhang, Wei-Dong.(2008).Abiesanol A, a novel biflavanol with unique six connective hexacyclic rings isolated from Abies georgei.TETRAHEDRON LETTERS,49(19),3042-3044. |
| MLA | Yang, Xian-Wen,et al."Abiesanol A, a novel biflavanol with unique six connective hexacyclic rings isolated from Abies georgei".TETRAHEDRON LETTERS 49.19(2008):3042-3044. |
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