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题名: Abiesanol A, a novel biflavanol with unique six connective hexacyclic rings isolated from Abies georgei
作者: Yang, Xian-Wen1; Li, Su-Mei2; Feng, Lin3; Shen, Yun-Heng1; Tian, Jun-Mian1; Zeng, Hua-Wu1; Liu, Xiao-Hua1; Shan, Lei1; Su, Juan1; Zhang, Chuan1; Zhang, Wei-Dong1, 4
刊名: TETRAHEDRON LETTERS
关键词: Abies georgei ; pinaceae ; biflavanol ; abiesanol A ; nitric oxide (NO) ; RAW264.7 macrophages
英文摘要: A novel biffavanol with unique six connective hexacyclic rings, abiesanol A (1), was isolated from the aerial parts of Abies georgei together with four known flavanols. The structure of new compound was elucidated mainly by the analysis of ID and 2D NMR spectroscopic data. In addition, single-crystal X-ray diffraction analysis was adopted to confirm the structure of abiesanol A (1). In biological assay for inhibitory activities against LPS-induced nitric oxide (NO) production in RAW264.7 macrophages, abiesanol A (1) showed potent effects at 50 mu g/mL with the inhibition rate of 43.0%. Under the same concentration, abiesanol A (1) did not show any cytotoxicity against RAW264.7 macrophages. (C) 2008 Elsevier Ltd. All rights reserved.
出版日期: 2008-05-05
卷号: 49, 期号:19, 页码:3042-3044
DOI标识: 10.1016/j.tetlet.2008.03.065
语种: 英语
收录类别: SCI ; IC
学科分类: Chemistry, Organic
ISSN号: 0040-4039
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/2927
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Second Mil Med Univ, Sch Pharm, Dept Nat Prod Chem, Shanghai 200433, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Dept Ethnobot, Kunming 650204, Peoples R China
3.Jiangxi Univ Tradit Chinese Med, Dept Pharm, Nanchang 330004, Peoples R China
4.Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China

Recommended Citation:
Yang, XW; Li, SM; Feng, L; Shen, YH; Tian, JM; Zeng, HW; Liu, XH; Shan, L; Su, J; Zhang, C; Zhang, WD.Abiesanol A, a novel biflavanol with unique six connective hexacyclic rings isolated from Abies georgei,TETRAHEDRON LETTERS,2008,49(19):3042-3044
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