Antifungal activity of C-27 steroidal saponins
Yang, CR; Zhang, Y; Jacob, MR; Khan, SI; Zhang, YJ; Li, XC
Corresponding Authorzhangyj@mail.kib.ac.cn ; xcli7@olemiss.edu
2006-05-01
Source PublicationANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN0066-4804
Volume50Issue:5Pages:1710-1714
AbstractAs part of our search for new antifungal agents from natural resources, 22 C-27 steroidal saponins and 6 steroidal sapogenins isolated from several monocotyledonous plants were tested for their antifungal activity against the opportunistic pathogens Candida albicans, Candida glabrata, Candida krusei, Cryptococcus neoformans, and Aspergillus fumigatus. The results showed that the antifungal activity of the steroidal saponins was associated with their aglycone moieties and the number and structure of monosaccharide units in their sugar chains. Within the 10 active saponins, four tigogenin saponins (compounds I to 4) with a sugar moiety of four or five monosaccharide units exhibited significant activity against C. neoformans and A. fumigatus, comparable to the positive control amphotericin B. The antifungal potency of these compounds was not associated with cytotoxicity to mammalian cells. This suggests that the C-27 steroidal saponins may be considered potential antifungal leads for further preclinical study.
KeywordFermented Leaves Agave-americana Candida-albicans Glycosides Resistance
Subject AreaMicrobiology ; Pharmacology & Pharmacy
DOI10.1128/AAC.50.5.1710-1714.2006
Indexed BySCI
Language英语
WOS Research AreaMicrobiology ; Pharmacology & Pharmacy
WOS SubjectMicrobiology ; Pharmacology & Pharmacy
WOS IDWOS:000237365300014
Citation statistics
Cited Times:134[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/2925
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.CAS, Kunming Inst Bot, Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Univ Mississippi, Sch Pharm, Pharmaceut Sci Res Inst, Natl Ctr Nat Prod Res, University, MS 38677 USA
Recommended Citation
GB/T 7714
Yang, CR,Zhang, Y,Jacob, MR,et al. Antifungal activity of C-27 steroidal saponins[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,2006,50(5):1710-1714.
APA Yang, CR,Zhang, Y,Jacob, MR,Khan, SI,Zhang, YJ,&Li, XC.(2006).Antifungal activity of C-27 steroidal saponins.ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,50(5),1710-1714.
MLA Yang, CR,et al."Antifungal activity of C-27 steroidal saponins".ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 50.5(2006):1710-1714.
Files in This Item: Download All
File Name/Size DocType Version Access License
201110180110.pdf(99KB) 开放获取--View Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Yang, CR]'s Articles
[Zhang, Y]'s Articles
[Jacob, MR]'s Articles
Baidu academic
Similar articles in Baidu academic
[Yang, CR]'s Articles
[Zhang, Y]'s Articles
[Jacob, MR]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Yang, CR]'s Articles
[Zhang, Y]'s Articles
[Jacob, MR]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: 201110180110.pdf
Format: Adobe PDF
This file does not support browsing at this time
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.