Antifungal activity of C-27 steroidal saponins
Yang, CR; Zhang, Y; Jacob, MR; Khan, SI; Zhang, YJ; Li, XC
Corresponding ;
AbstractAs part of our search for new antifungal agents from natural resources, 22 C-27 steroidal saponins and 6 steroidal sapogenins isolated from several monocotyledonous plants were tested for their antifungal activity against the opportunistic pathogens Candida albicans, Candida glabrata, Candida krusei, Cryptococcus neoformans, and Aspergillus fumigatus. The results showed that the antifungal activity of the steroidal saponins was associated with their aglycone moieties and the number and structure of monosaccharide units in their sugar chains. Within the 10 active saponins, four tigogenin saponins (compounds I to 4) with a sugar moiety of four or five monosaccharide units exhibited significant activity against C. neoformans and A. fumigatus, comparable to the positive control amphotericin B. The antifungal potency of these compounds was not associated with cytotoxicity to mammalian cells. This suggests that the C-27 steroidal saponins may be considered potential antifungal leads for further preclinical study.
KeywordFermented Leaves Agave-americana Candida-albicans Glycosides Resistance
Subject AreaMicrobiology ; Pharmacology & Pharmacy
Indexed BySCI
WOS Research AreaMicrobiology ; Pharmacology & Pharmacy
WOS SubjectMicrobiology ; Pharmacology & Pharmacy
WOS IDWOS:000237365300014
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Cited Times:134[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Affiliation1.CAS, Kunming Inst Bot, Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Univ Mississippi, Sch Pharm, Pharmaceut Sci Res Inst, Natl Ctr Nat Prod Res, University, MS 38677 USA
Recommended Citation
GB/T 7714
Yang, CR,Zhang, Y,Jacob, MR,et al. Antifungal activity of C-27 steroidal saponins[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,2006,50(5):1710-1714.
APA Yang, CR,Zhang, Y,Jacob, MR,Khan, SI,Zhang, YJ,&Li, XC.(2006).Antifungal activity of C-27 steroidal saponins.ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,50(5),1710-1714.
MLA Yang, CR,et al."Antifungal activity of C-27 steroidal saponins".ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 50.5(2006):1710-1714.
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