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题名: Antifungal activity of C-27 steroidal saponins
作者: Yang, CR; Zhang, Y; Jacob, MR; Khan, SI; null(张颖君); Li, XC
刊名: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
关键词: FERMENTED LEAVES ; AGAVE-AMERICANA ; CANDIDA-ALBICANS ; GLYCOSIDES ; RESISTANCE
英文摘要: As part of our search for new antifungal agents from natural resources, 22 C-27 steroidal saponins and 6 steroidal sapogenins isolated from several monocotyledonous plants were tested for their antifungal activity against the opportunistic pathogens Candida albicans, Candida glabrata, Candida krusei, Cryptococcus neoformans, and Aspergillus fumigatus. The results showed that the antifungal activity of the steroidal saponins was associated with their aglycone moieties and the number and structure of monosaccharide units in their sugar chains. Within the 10 active saponins, four tigogenin saponins (compounds I to 4) with a sugar moiety of four or five monosaccharide units exhibited significant activity against C. neoformans and A. fumigatus, comparable to the positive control amphotericin B. The antifungal potency of these compounds was not associated with cytotoxicity to mammalian cells. This suggests that the C-27 steroidal saponins may be considered potential antifungal leads for further preclinical study.
出版日期: 2006-05-01
卷号: 50, 期号:5, 页码:1710-1714
DOI标识: 10.1128/AAC.50.5.1710-1714.2006
语种: 英语
ISSN号: 0066-4804
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/2925
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.CAS, Kunming Inst Bot, Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Univ Mississippi, Sch Pharm, Pharmaceut Sci Res Inst, Natl Ctr Nat Prod Res, University, MS 38677 USA

Recommended Citation:
Yang, CR; Zhang, Y; Jacob, MR; Khan, SI; Zhang, YJ; Li, XC.Antifungal activity of C-27 steroidal saponins,ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,2006,50(5):1710-1714
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