Antifungal activity of C-27 steroidal saponins
Yang, CR; Zhang, Y; Jacob, MR; Khan, SI; Zhang, YJ; Li, XC
2006-05-01
发表期刊ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN0066-4804
卷号50期号:5页码:1710-1714
摘要As part of our search for new antifungal agents from natural resources, 22 C-27 steroidal saponins and 6 steroidal sapogenins isolated from several monocotyledonous plants were tested for their antifungal activity against the opportunistic pathogens Candida albicans, Candida glabrata, Candida krusei, Cryptococcus neoformans, and Aspergillus fumigatus. The results showed that the antifungal activity of the steroidal saponins was associated with their aglycone moieties and the number and structure of monosaccharide units in their sugar chains. Within the 10 active saponins, four tigogenin saponins (compounds I to 4) with a sugar moiety of four or five monosaccharide units exhibited significant activity against C. neoformans and A. fumigatus, comparable to the positive control amphotericin B. The antifungal potency of these compounds was not associated with cytotoxicity to mammalian cells. This suggests that the C-27 steroidal saponins may be considered potential antifungal leads for further preclinical study.
关键词Fermented Leaves Agave-americana Candida-albicans Glycosides Resistance
学科领域Microbiology ; Pharmacology & Pharmacy
DOI10.1128/AAC.50.5.1710-1714.2006
收录类别SCI
语种英语
WOS研究方向Microbiology ; Pharmacology & Pharmacy
WOS类目Microbiology ; Pharmacology & Pharmacy
WOS记录号WOS:000237365300014
引用统计
被引频次:122[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/2925
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.CAS, Kunming Inst Bot, Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Univ Mississippi, Sch Pharm, Pharmaceut Sci Res Inst, Natl Ctr Nat Prod Res, University, MS 38677 USA
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Yang, CR,Zhang, Y,Jacob, MR,et al. Antifungal activity of C-27 steroidal saponins[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,2006,50(5):1710-1714.
APA Yang, CR,Zhang, Y,Jacob, MR,Khan, SI,Zhang, YJ,&Li, XC.(2006).Antifungal activity of C-27 steroidal saponins.ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,50(5),1710-1714.
MLA Yang, CR,et al."Antifungal activity of C-27 steroidal saponins".ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 50.5(2006):1710-1714.
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