Antifungal activity of C-27 steroidal saponins

doi:10.1128/AAC.50.5.1710-1714.2006

	Antifungal activity of C-27 steroidal saponins
	Yang, CR ; Zhang, Y; Jacob, MR ; Khan, SI ; Zhang, YJ; Li, XC
通讯作者	zhangyj@mail.kib.ac.cn ; xcli7@olemiss.edu
	2006-05-01
发表期刊	ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN	0066-4804
卷号	50 期号:5 页码:1710-1714
摘要	As part of our search for new antifungal agents from natural resources, 22 C-27 steroidal saponins and 6 steroidal sapogenins isolated from several monocotyledonous plants were tested for their antifungal activity against the opportunistic pathogens Candida albicans, Candida glabrata, Candida krusei, Cryptococcus neoformans, and Aspergillus fumigatus. The results showed that the antifungal activity of the steroidal saponins was associated with their aglycone moieties and the number and structure of monosaccharide units in their sugar chains. Within the 10 active saponins, four tigogenin saponins (compounds I to 4) with a sugar moiety of four or five monosaccharide units exhibited significant activity against C. neoformans and A. fumigatus, comparable to the positive control amphotericin B. The antifungal potency of these compounds was not associated with cytotoxicity to mammalian cells. This suggests that the C-27 steroidal saponins may be considered potential antifungal leads for further preclinical study.
关键词	Fermented Leaves Agave-americana Candida-albicans Glycosides Resistance
学科领域	Microbiology ; Pharmacology & Pharmacy
DOI	10.1128/AAC.50.5.1710-1714.2006
收录类别	SCI
语种	英语
WOS记录号	WOS:000237365300014
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/2925
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.CAS, Kunming Inst Bot, Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Univ Mississippi, Sch Pharm, Pharmaceut Sci Res Inst, Natl Ctr Nat Prod Res, University, MS 38677 USA
推荐引用方式 GB/T 7714	Yang, CR,Zhang, Y,Jacob, MR,et al. Antifungal activity of C-27 steroidal saponins[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,2006,50(5):1710-1714.
APA	Yang, CR,Zhang, Y,Jacob, MR,Khan, SI,Zhang, YJ,&Li, XC.(2006).Antifungal activity of C-27 steroidal saponins.ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,50(5),1710-1714.
MLA	Yang, CR,et al."Antifungal activity of C-27 steroidal saponins".ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 50.5(2006):1710-1714.

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