Anti-HBV agents. Part 2: Synthesis and in vitro anti-hepatitis B virus activities of alisol A derivatives

doi:10.1016/j.bmcl.2009.02.122

	Anti-HBV agents. Part 2: Synthesis and in vitro anti-hepatitis B virus activities of alisol A derivatives
	Zhang, Quan 1,2; Jiang, Zhi-Yong 1; Luo, Jie 1; Liu, Ji-Feng 1,2; Ma, Yun-Bao 1; Guo, Rui-Hua 1,2; Zhang, Xue-Mei1 ; Zhou, Jun1 ; Chen, Ji-Jun1
	2009-04-15
发表期刊	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN	0960-894X
卷号	19 期号:8 页码:2148-2153
摘要	Chemical modi. cations were performed on hydroxyl groups at C-11,23,24,25 positions and C-13(17) double bond of alisol A for structure-activity relationship study. Forty-one derivatives of alisol A were synthesized and assayed for their in vitro anti-hepatitis B virus (HBV) activities and cytotoxicities. Of them, 14 compounds were active against HBV surface antigen (HBsAg) and HBV e antigen (HBeAg) secretion in HepG 2.2.15 cells, and the most promising compound 25 exhibited high activities against secretion of HBsAg (IC(50) = 0.028 mM), HBeAg (IC(50) = 0.027 mM) and remarkable selective indices (SI(HBsAg) > 90, SI(HBeAg) > 93). (C) 2009 Elsevier Ltd. All rights reserved.
关键词	Anti-hbv Activity Protostane-type Triterpene Alisol a Derivatives Chemical Modification
学科领域	Chemistry, Medicinal ; Chemistry, Organic
DOI	10.1016/j.bmcl.2009.02.122
收录类别	SCI
语种	英语
WOS记录号	WOS:000264706800012
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/2913
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Quan,Jiang, Zhi-Yong,Luo, Jie,et al. Anti-HBV agents. Part 2: Synthesis and in vitro anti-hepatitis B virus activities of alisol A derivatives[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2009,19(8):2148-2153.
APA	Zhang, Quan.,Jiang, Zhi-Yong.,Luo, Jie.,Liu, Ji-Feng.,Ma, Yun-Bao.,...&Chen, Ji-Jun.(2009).Anti-HBV agents. Part 2: Synthesis and in vitro anti-hepatitis B virus activities of alisol A derivatives.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,19(8),2148-2153.
MLA	Zhang, Quan,et al."Anti-HBV agents. Part 2: Synthesis and in vitro anti-hepatitis B virus activities of alisol A derivatives".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 19.8(2009):2148-2153.

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