Anti-HBV agents. Part 2: Synthesis and in vitro anti-hepatitis B virus activities of alisol A derivatives
Zhang, Quan1,2; Jiang, Zhi-Yong1; Luo, Jie1; Liu, Ji-Feng1,2; Ma, Yun-Bao1; Guo, Rui-Hua1,2; Zhang, Xue-Mei1; Zhou, Jun1; Chen, Ji-Jun1
2009-04-15
Source PublicationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN0960-894X
Volume19Issue:8Pages:2148-2153
AbstractChemical modi. cations were performed on hydroxyl groups at C-11,23,24,25 positions and C-13(17) double bond of alisol A for structure-activity relationship study. Forty-one derivatives of alisol A were synthesized and assayed for their in vitro anti-hepatitis B virus (HBV) activities and cytotoxicities. Of them, 14 compounds were active against HBV surface antigen (HBsAg) and HBV e antigen (HBeAg) secretion in HepG 2.2.15 cells, and the most promising compound 25 exhibited high activities against secretion of HBsAg (IC(50) = 0.028 mM), HBeAg (IC(50) = 0.027 mM) and remarkable selective indices (SI(HBsAg) > 90, SI(HBeAg) > 93). (C) 2009 Elsevier Ltd. All rights reserved.
KeywordAnti-hbv Activity Protostane-type Triterpene Alisol a Derivatives Chemical Modification
Subject AreaChemistry, Medicinal ; Chemistry, Organic
DOI10.1016/j.bmcl.2009.02.122
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy ; Chemistry
WOS SubjectChemistry, Medicinal ; Chemistry, Organic
WOS IDWOS:000264706800012
Citation statistics
Cited Times:24[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/2913
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Quan,Jiang, Zhi-Yong,Luo, Jie,et al. Anti-HBV agents. Part 2: Synthesis and in vitro anti-hepatitis B virus activities of alisol A derivatives[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2009,19(8):2148-2153.
APA Zhang, Quan.,Jiang, Zhi-Yong.,Luo, Jie.,Liu, Ji-Feng.,Ma, Yun-Bao.,...&Chen, Ji-Jun.(2009).Anti-HBV agents. Part 2: Synthesis and in vitro anti-hepatitis B virus activities of alisol A derivatives.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,19(8),2148-2153.
MLA Zhang, Quan,et al."Anti-HBV agents. Part 2: Synthesis and in vitro anti-hepatitis B virus activities of alisol A derivatives".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 19.8(2009):2148-2153.
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