Anti-HBV agents. Part 2: Synthesis and in vitro anti-hepatitis B virus activities of alisol A derivatives
Zhang, Quan1,2; Jiang, Zhi-Yong1; Luo, Jie1; Liu, Ji-Feng1,2; Ma, Yun-Bao1; Guo, Rui-Hua1,2; Zhang, Xue-Mei1; Zhou, Jun1; Chen, Ji-Jun1
2009-04-15
发表期刊BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN0960-894X
卷号19期号:8页码:2148-2153
摘要Chemical modi. cations were performed on hydroxyl groups at C-11,23,24,25 positions and C-13(17) double bond of alisol A for structure-activity relationship study. Forty-one derivatives of alisol A were synthesized and assayed for their in vitro anti-hepatitis B virus (HBV) activities and cytotoxicities. Of them, 14 compounds were active against HBV surface antigen (HBsAg) and HBV e antigen (HBeAg) secretion in HepG 2.2.15 cells, and the most promising compound 25 exhibited high activities against secretion of HBsAg (IC(50) = 0.028 mM), HBeAg (IC(50) = 0.027 mM) and remarkable selective indices (SI(HBsAg) > 90, SI(HBeAg) > 93). (C) 2009 Elsevier Ltd. All rights reserved.
关键词Anti-hbv Activity Protostane-type Triterpene Alisol a Derivatives Chemical Modification
资助信息National Natural Science Foundation of China (NSFC) [30672522]; Xibu Zhiguang Joint-Scholarship of Chinese Academy of Sciences ; External Cooperation Program of Chinese Academy of Sciences [GJHZ200818]; CAS-Croucher Foundation [CAS-CF07/08.SC03]
学科领域Chemistry, Medicinal ; Chemistry, Organic
DOI10.1016/j.bmcl.2009.02.122
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy ; Chemistry
WOS类目Chemistry, Medicinal ; Chemistry, Organic
WOS记录号WOS:000264706800012
引用统计
被引频次:24[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/2913
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
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Zhang, Quan,Jiang, Zhi-Yong,Luo, Jie,et al. Anti-HBV agents. Part 2: Synthesis and in vitro anti-hepatitis B virus activities of alisol A derivatives[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2009,19(8):2148-2153.
APA Zhang, Quan.,Jiang, Zhi-Yong.,Luo, Jie.,Liu, Ji-Feng.,Ma, Yun-Bao.,...&Chen, Ji-Jun.(2009).Anti-HBV agents. Part 2: Synthesis and in vitro anti-hepatitis B virus activities of alisol A derivatives.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,19(8),2148-2153.
MLA Zhang, Quan,et al."Anti-HBV agents. Part 2: Synthesis and in vitro anti-hepatitis B virus activities of alisol A derivatives".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 19.8(2009):2148-2153.
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