Cytotoxic Triterpenoid Alkaloids from Buxus microphylla
Yan, Yu-Xin1,2; Hu, Xiao-Dong3; Chen, Jian-Chao1; Sun, Yun1,2; Zhang, Xian-Min1; Qing, Chen3; Qiu, Ming-Hua1,2
2009-02-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号72期号:2页码:308-311
摘要Five new triterpenoid alkaloids, buxmicrophyllines E-I (1-5), and six known ones (6-11) were isolated from the leaves and stems of Buxus microphylla. The structures of compounds 1-5 were elucidated by NMR and MS spectroscopic analysis, and the relative stereochemistry of 5 was determined by single-crystal X-ray crystallography. Compounds 3 and 9 were cytotoxic against HepG2 cells, with IC(50) values of 0.89 and 0.78 mu M, and compounds 2, 3, 7, 8, and 9 were cytotoxic against K562 cells, with IC(50) values of 2.95, 4.44, 1.70, 5.61, and 0.37 mu M, respectively.
关键词Hyrcana Assay
资助信息Knowledge Innovation Program of the CAS [KSCX2-YW-G-038, KSCX2-YW-G-027]; NSFC [30772636]; NSFY [2005C0010Z]; High-Tech Special Project of Yunnan Province ; Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China
收录类别SCI ; IC
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/2889
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
3.Kunming Med Coll, Yunnan Key Lab Pharmacol Nat Prod Res, Kunming 650031, Yunnan, Peoples R China
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GB/T 7714
Yan, Yu-Xin,Hu, Xiao-Dong,Chen, Jian-Chao,et al. Cytotoxic Triterpenoid Alkaloids from Buxus microphylla[J]. JOURNAL OF NATURAL PRODUCTS,2009,72(2):308-311.
APA Yan, Yu-Xin.,Hu, Xiao-Dong.,Chen, Jian-Chao.,Sun, Yun.,Zhang, Xian-Min.,...&Qiu, Ming-Hua.(2009).Cytotoxic Triterpenoid Alkaloids from Buxus microphylla.JOURNAL OF NATURAL PRODUCTS,72(2),308-311.
MLA Yan, Yu-Xin,et al."Cytotoxic Triterpenoid Alkaloids from Buxus microphylla".JOURNAL OF NATURAL PRODUCTS 72.2(2009):308-311.
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