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题名: Cytotoxic Triterpenoid Alkaloids from Buxus microphylla
作者: Yan, Yu-Xin1, 2; Hu, Xiao-Dong3; Chen, Jian-Chao1; Sun, Yun1, 2; Zhang, Xian-Min1; Qing, Chen3; null(邱明华)1, 2
刊名: JOURNAL OF NATURAL PRODUCTS
关键词: HYRCANA ; ASSAY
英文摘要: Five new triterpenoid alkaloids, buxmicrophyllines E-I (1-5), and six known ones (6-11) were isolated from the leaves and stems of Buxus microphylla. The structures of compounds 1-5 were elucidated by NMR and MS spectroscopic analysis, and the relative stereochemistry of 5 was determined by single-crystal X-ray crystallography. Compounds 3 and 9 were cytotoxic against HepG2 cells, with IC(50) values of 0.89 and 0.78 mu M, and compounds 2, 3, 7, 8, and 9 were cytotoxic against K562 cells, with IC(50) values of 2.95, 4.44, 1.70, 5.61, and 0.37 mu M, respectively.
出版日期: 2009-02-01
卷号: 72, 期号:2, 页码:308-311
语种: 英语
收录类别: SCI ; IC
学科分类: Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy
ISSN号: 0163-3864
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/2889
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
3.Kunming Med Coll, Yunnan Key Lab Pharmacol Nat Prod Res, Kunming 650031, Yunnan, Peoples R China

Recommended Citation:
Yan, YX; Hu, XD; Chen, JC; Sun, Y; Zhang, XM; Qing, C; Qiu, MH.Cytotoxic Triterpenoid Alkaloids from Buxus microphylla,JOURNAL OF NATURAL PRODUCTS,2009,72(2):308-311
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