Steroidal saponins and cytoxicity of the wild edible vegetable-Smilacina atropurpurea

doi:10.1016/j.steroids.2008.08.008

	Steroidal saponins and cytoxicity of the wild edible vegetable-Smilacina atropurpurea
	Yang, Shun-Li 1; Liu, Xi-Kui 1; Wu, Hui 2; Wang, Hai-Bo 1; Qing, Chen 2
	2009
发表期刊	STEROIDS
ISSN	0039-128X
卷号	74 期号:1 页码:7-12
摘要	Four new steroidal saponins, smilacinoside A (1), B (2), C (3), and D (4), together with three known saponins, funkioside D (5), aspidistrin (6) and 26-O-beta-D-glucopyranosyl-22-methoxyl-(25R)-furost-5-en-3 beta,26-diol-3-O-beta-D-glucopyranosyl-(1 -> 2)-beta-D-glucopyranosyl-(1 -> 4)-beta-D-galactopyranoside (7) were isolated from the dried tender aerial parts of Smilacina atropurpurea (Franch.) Wang et Tang. The structures of new compounds were elucidated as diosgenin 3-O-alpha-L-rhamnopyranosyl-(1 -> 2)-O-beta-D-galactopyranoside (1), diosgenin 3-O-alpha-L-rhamnopyranosyl-(1 -> 3)-[6-O-palmitoxyl]-O-beta-D-galactopyranoside (2), 26-O-beta-D-glucopyrariosyl-(25R)-furost-5-en-3 beta,22 xi,26-triol 3-O-alpha-L-rhamnopyranosyl-(1 -> 2)}-beta-D-galactopyrarioside (3) and 26-O-beta-D-glucopyranosyl-22-methoxyl-(25R)-furost-5-en-3 beta,26-diol 3-O-alpha-L-rhamnopyranosyl-(1 -> 2)-beta-D-galactopyranoside (4) on the basis of chemical methods and detailed spectroscopic analysis, including 1D and 2D NMR techniques and single-crystal X-ray diffraction, respectively. Six of these compounds and MeOH extract were tested for their in vitro cytotoxicity toward K562 human tumor cells by an improved MTT method. Smilacinoside A, funkioside D and aspidistrin exhibited significant in vitro cytotoxicity against K562 with IC(50) values of 1.09, 2.93 and 0.47 mu g/mL, respectively. (C) 2008 Elsevier Inc. All rights reserved.
关键词	Smilacina Atropurpurea Cytoxicity Smilacinoside A-d Steroidal Saponin
学科领域	Biochemistry & Molecular Biology ; Endocrinology & Metabolism
DOI	10.1016/j.steroids.2008.08.008
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000262895500002
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/2881
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China 2.Kunming Med Coll, Yunnan Pharmacol Lab Nat Prod, Kunming 650031, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Yang, Shun-Li,Liu, Xi-Kui,Wu, Hui,et al. Steroidal saponins and cytoxicity of the wild edible vegetable-Smilacina atropurpurea[J]. STEROIDS,2009,74(1):7-12.
APA	Yang, Shun-Li,Liu, Xi-Kui,Wu, Hui,Wang, Hai-Bo,&Qing, Chen.(2009).Steroidal saponins and cytoxicity of the wild edible vegetable-Smilacina atropurpurea.STEROIDS,74(1),7-12.
MLA	Yang, Shun-Li,et al."Steroidal saponins and cytoxicity of the wild edible vegetable-Smilacina atropurpurea".STEROIDS 74.1(2009):7-12.

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