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题名: Steroidal saponins and cytoxicity of the wild edible vegetable-Smilacina atropurpurea
作者: Yang, Shun-Li1; Liu, Xi-Kui1; Wu, Hui2; Wang, Hai-Bo1; Qing, Chen2
刊名: STEROIDS
关键词: Smilacina atropurpurea ; Cytoxicity ; Smilacinoside A-D ; Steroidal saponin
英文摘要: Four new steroidal saponins, smilacinoside A (1), B (2), C (3), and D (4), together with three known saponins, funkioside D (5), aspidistrin (6) and 26-O-beta-D-glucopyranosyl-22-methoxyl-(25R)-furost-5-en-3 beta,26-diol-3-O-beta-D-glucopyranosyl-(1 -> 2)-beta-D-glucopyranosyl-(1 -> 4)-beta-D-galactopyranoside (7) were isolated from the dried tender aerial parts of Smilacina atropurpurea (Franch.) Wang et Tang. The structures of new compounds were elucidated as diosgenin 3-O-alpha-L-rhamnopyranosyl-(1 -> 2)-O-beta-D-galactopyranoside (1), diosgenin 3-O-alpha-L-rhamnopyranosyl-(1 -> 3)-[6-O-palmitoxyl]-O-beta-D-galactopyranoside (2), 26-O-beta-D-glucopyrariosyl-(25R)-furost-5-en-3 beta,22 xi,26-triol 3-O-alpha-L-rhamnopyranosyl-(1 -> 2)}-beta-D-galactopyrarioside (3) and 26-O-beta-D-glucopyranosyl-22-methoxyl-(25R)-furost-5-en-3 beta,26-diol 3-O-alpha-L-rhamnopyranosyl-(1 -> 2)-beta-D-galactopyranoside (4) on the basis of chemical methods and detailed spectroscopic analysis, including 1D and 2D NMR techniques and single-crystal X-ray diffraction, respectively. Six of these compounds and MeOH extract were tested for their in vitro cytotoxicity toward K562 human tumor cells by an improved MTT method. Smilacinoside A, funkioside D and aspidistrin exhibited significant in vitro cytotoxicity against K562 with IC(50) values of 1.09, 2.93 and 0.47 mu g/mL, respectively. (C) 2008 Elsevier Inc. All rights reserved.
出版日期: 2009
卷号: 74, 期号:1, 页码:7-12
DOI标识: 10.1016/j.steroids.2008.08.008
语种: 英语
收录类别: SCI ; IC
学科分类: Biochemistry & Molecular Biology; Endocrinology & Metabolism
ISSN号: 0039-128X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/2881
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
2.Kunming Med Coll, Yunnan Pharmacol Lab Nat Prod, Kunming 650031, Yunnan, Peoples R China

Recommended Citation:
Yang, SL; Liu, XK; Wu, H; Wang, HB; Qing, C.Steroidal saponins and cytoxicity of the wild edible vegetable-Smilacina atropurpurea,STEROIDS,2009,74(1):7-12
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