Steroidal saponins and cytoxicity of the wild edible vegetable-Smilacina atropurpurea
Yang, Shun-Li1; Liu, Xi-Kui1; Wu, Hui2; Wang, Hai-Bo1; Qing, Chen2
2009
发表期刊STEROIDS
ISSN0039-128X
卷号74期号:1页码:7-12
摘要Four new steroidal saponins, smilacinoside A (1), B (2), C (3), and D (4), together with three known saponins, funkioside D (5), aspidistrin (6) and 26-O-beta-D-glucopyranosyl-22-methoxyl-(25R)-furost-5-en-3 beta,26-diol-3-O-beta-D-glucopyranosyl-(1 -> 2)-beta-D-glucopyranosyl-(1 -> 4)-beta-D-galactopyranoside (7) were isolated from the dried tender aerial parts of Smilacina atropurpurea (Franch.) Wang et Tang. The structures of new compounds were elucidated as diosgenin 3-O-alpha-L-rhamnopyranosyl-(1 -> 2)-O-beta-D-galactopyranoside (1), diosgenin 3-O-alpha-L-rhamnopyranosyl-(1 -> 3)-[6-O-palmitoxyl]-O-beta-D-galactopyranoside (2), 26-O-beta-D-glucopyrariosyl-(25R)-furost-5-en-3 beta,22 xi,26-triol 3-O-alpha-L-rhamnopyranosyl-(1 -> 2)}-beta-D-galactopyrarioside (3) and 26-O-beta-D-glucopyranosyl-22-methoxyl-(25R)-furost-5-en-3 beta,26-diol 3-O-alpha-L-rhamnopyranosyl-(1 -> 2)-beta-D-galactopyranoside (4) on the basis of chemical methods and detailed spectroscopic analysis, including 1D and 2D NMR techniques and single-crystal X-ray diffraction, respectively. Six of these compounds and MeOH extract were tested for their in vitro cytotoxicity toward K562 human tumor cells by an improved MTT method. Smilacinoside A, funkioside D and aspidistrin exhibited significant in vitro cytotoxicity against K562 with IC(50) values of 1.09, 2.93 and 0.47 mu g/mL, respectively. (C) 2008 Elsevier Inc. All rights reserved.
关键词Smilacina Atropurpurea Cytoxicity Smilacinoside A-d Steroidal Saponin
资助信息Natural Science Foundation of Yunnan Province of China [2005B0049 M, 2000C0001 P]
学科领域Biochemistry & Molecular Biology ; Endocrinology & Metabolism
DOI10.1016/j.steroids.2008.08.008
收录类别SCI ; IC
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS类目Biochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS记录号WOS:000262895500002
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/2881
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
2.Kunming Med Coll, Yunnan Pharmacol Lab Nat Prod, Kunming 650031, Yunnan, Peoples R China
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Yang, Shun-Li,Liu, Xi-Kui,Wu, Hui,et al. Steroidal saponins and cytoxicity of the wild edible vegetable-Smilacina atropurpurea[J]. STEROIDS,2009,74(1):7-12.
APA Yang, Shun-Li,Liu, Xi-Kui,Wu, Hui,Wang, Hai-Bo,&Qing, Chen.(2009).Steroidal saponins and cytoxicity of the wild edible vegetable-Smilacina atropurpurea.STEROIDS,74(1),7-12.
MLA Yang, Shun-Li,et al."Steroidal saponins and cytoxicity of the wild edible vegetable-Smilacina atropurpurea".STEROIDS 74.1(2009):7-12.
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