Isolation and Asymmetric Total Synthesis of Perforanoid A

doi:10.1002/anie.201602783

	Isolation and Asymmetric Total Synthesis of Perforanoid A
	Lv, Chao; Yan, Xiaohui; Tu, Qian; Di, Yingtong; Yuan, Chunmao; Fang, Xin; Ben-David, Yaacove; Xia, Lei; Gong, Jianxian; Shen, Yuemao; Yang, Zhen; Hao, Xiaojiang
	2016-06-20
发表期刊	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷号	55 期号:26 页码:7539-7543
摘要	A novel limonoid, perforanoid A, was isolated, and an asymmetric total synthesis was achieved in 10 steps. The key steps are chiral tertiary aminonaphthol mediated enantioselective alkenylation of an aldehyde to an allylic alcohol, Pd-catalyzed coupling of the allylic alcohol with vinyl ether to form the gamma-lactone ring, and cyclopentenone ring formation through a Rh-catalyzed Pauson-Khand reaction. Preliminary studies show that perforanoid A is cytotoxic towards HEL, K562, and CB3 tumor cell lines.
关键词	Asymmetric Synthesis Cytotoxicity Limonoids Pauson-khand Reaction Total Synthesis
DOI	10.1002/anie.201602783
收录类别	SCI
语种	英语
WOS记录号	WOS:000383077400042
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/28626
专题	植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Lv, Chao,Yan, Xiaohui,Tu, Qian,et al. Isolation and Asymmetric Total Synthesis of Perforanoid A[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2016,55(26):7539-7543.
APA	Lv, Chao.,Yan, Xiaohui.,Tu, Qian.,Di, Yingtong.,Yuan, Chunmao.,...&Hao, Xiaojiang.(2016).Isolation and Asymmetric Total Synthesis of Perforanoid A.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,55(26),7539-7543.
MLA	Lv, Chao,et al."Isolation and Asymmetric Total Synthesis of Perforanoid A".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 55.26(2016):7539-7543.

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